Summary
-
I.
The bibliography about corticosteroid influence on immune response is briefly reviewed. Generally, it is admitted that corticosteroids are immunosuppressive when administered in large amounts. Divergent opinions are recalled.
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II.
The aims of the experiments are summarized:
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A)
Investigate on the influence of corticoids (given in just substitutive amounts) on skin allograft rejection.
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B)
Investigate on possible interactions between adrenal cortex and thymus with this test.
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III.
It was observed, that
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A)
Adrenalectomy resulted in a significant delay of allograft rejection.
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B)
This could be suppressed partially by administering aldosterone, corticosterone, and desoxycorticosterone and completely by administering at least two of these hormones.
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C)
Cortisol had shown a minor inhibitory influence.
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D)
There was no obvious difference between adrenalectomized and thymectomized rats and those adrenalectomized only.
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IV.
These observations are replaced in the context of bibliography and their significance is discussed.
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References
Abraham, A., Sekeris, C.: Biochim. Biophys. Acta247, 562 (1971)
Agosier, M., Christen, R., Badinaz, O., Gasic, G.: Proc. Soc. Exp. Bio. Med.80, 128 (1952)
Ambrose, C. T.: J. Exp. Med.119, 1027 (1964)
Aschkenasy, A., Bussard, A., Corvazier, P., Grabar, P.: Rev. d'Hématol,5, 107, 130 (1950)
Bach, J. F., Duval, D., Dardenne, M., Salomon, J. C., Tursz, T., Fournier, C.: Transplantat. Proc.7, 43 (1975)
Bathmann, A., Land, W., Koczorek, K. P., Stass, P., Brendel, W.: Eur. Surg. Res.3, 40, 51 (1971)
Berglund, K.: Acta Path. Microbiol. Scand.38, 311 (1956)
Berglund, K., Fagraeus, A.: Nature177, 233 (1956)
Bernardi, G., Comsa, J.: Experientia21, 416 (1965)
Besedowsky, H. O., Sorkin, E., Keller, M., Müller, J.: Proc. Soc. Exp. Biol. Med.150, 466 (1975)
Besedowsky, H. O., Sorkin, E.: J. Clin. Exp. Immunol.27, 176 (1977)
Billingham, R. E., Krohn, P., Medawar, P. B.: Br. Med. J.1951 I, 1157
Bisset, K. A.: J. Endocrinol.6, 94 (1949)
Bjoerneboe, M., Fischel, E. E., Stoerk, E.: J. Exp. Med.93, 37 (1951)
Blecher, M., White, A.: Endocrinology63, 65 (1958)
Blomgren, H., Anderson, B.: Exp. Cell. Res.57, 185 (1969)
Boyett, J. D., Hoffert, J. F.: Endocrinology91, 233 (1972)
Brunck-Johnson, T., Dougherty, T. F.: Acta Endocrinol.49, 471 (1965)
Cannon, J. A., Longmuir, W. P.: Ann. Surg.135, 60 (1952)
Castro, J. F., Hamilton, D. N. H.: Transplantation13, 614 (1972)
Chebotarev, V. F.: Vopr. Immunol.3, 35 (1968)
Claman, H. N., Moorhead, J. W., Berner, W. H.: J. Labor. Clin. Med.79, 499 (1971)
Cohen, J. J., Claman, H. N.: J. Exp. Med.133, 1026 (1971)
Cohen, J. J., Fischbach, M., Claman, H. N.: J. Immunol.105, 1146 (1970)
Comsa, J.: Nature182, 57 (1958)
Comsa, J., Leonhardt, H.: J. Physiol. (Paris)73, 36A (1977)
Comsa, J., Leonhardt, H.: Acta Endocrinol. Suppl.212, 258 (1977)
Comsa, J., Leonhardt, H., Schwarz, J. A.: Am. N.Y. Acad. Sci.249, 387 (1975)
Dempster, W. J.: Arch. Int. Pharm.95, 253 (1953)
Diamantstein, T.: Arch. Klin. Exp. HNO196, 76 (1970)
Dougherty, T. F.: Physiol. Rev.32, 379 (1952)
Dougherty, T. F., Berliner, M. Z., Schneebeli, G., Berliner, D.: Ann. N.Y. Acad. Sci.113, 825 (1963)
Dougherty, T. F., Chase, J. H., White, A.: Proc. Soc. Exp. Biol. Med.58, 135 (1948)
Dukor, P., Dietrich, F. M.: Int. Arch. Allergy Appl. Immunol.32, 131 (1967)
Eisen, H. N., Moore, D. H., Mayer, M. M., Tarr, R. R., Stoerk, H. C.: Proc. Soc. Exp. Biol. Med.65, 301 (1947)
Ellison, E. H., Martin, B. C., Williams, R. D., Chatworthy, H. W., Hamwi, G., Zollinger, R. M.: Ann. Surg.134, 495 (1951)
Fagraeus, A.: Scand. Acta Path. Microbiol. Suppl.93, 20 (1952)
Ferreira, A., Moreno, C., Hoecker, G.: Immunol.24, 607 (1973)
Fischel, E. E.: Bull. N.Y. Acad. Med.29, 255 (1953)
Fischel, E. E., Vaughan, J. A., Photopulos, C.: Proc. Soc. Exp. Biol. Med.81, 344 (1952)
Fox, C. A., Whitehead, R. N.: J. Immunol.30, 51 (1936)
Fox, K. E., Gabornel, J. D.: Endocrinology90, 1388 (1972)
Germuth, E. G., Oyama, J., Ottinger, B.: J. Exp. Med.94, 139 (1951)
Gisler, R. N.: Psychother. Psychosom.23, 197 (1974)
Glick, B.: J. Immunol.98, 1076 (1967)
Graff, R. J., Lappe, M. A., Snell, G. D.: Transplantation7, 105 (1969)
Greengard, O.: Biochim. Biophys. Acta286, 382 (1972)
Halpern, B. N., Mauric, G., Holtzer, A., Briot, M.: Acta Allergol4, 207 (1951)
Hayes, S. P., Dougherty, T. F.: Feder. Proc.11, 67 (1952)
Hellig, H., Waldek, J. F.: Oderstepoort J. Veter. Res.41, 29 (1974)
Jaffe, H. L., Marine, D.: J. Infect. Dis.35, 334 (1924)
Jerne, K., Nordin, A. A.: Science140, 405 (1963)
Kass, E. H., Kendrick, M. L., Finland, M.: J. Exp. Med.102, 767 (1955)
Kemp, R. G., Duquesnoy, R. J.: J. Immunol.114, 660 (1975)
Kinberg, D. V., Loeb, J. H.: Biochim. Biophys. Acta246, 412 (1971)
Kinoshita, Y.: Exp. Cell. Res.87, 387 (1974)
Knigge, K. M., Pernod, C. H., Schindler, W. J.: Am. J. Physiol.196, 579 (1959)
Krohn, P. L.: J. Endocrinol.11, 78 (1954)
Lambert, A., Stoerk, H. C.: Feder. Proc.13, 1 (1954)
Lee, K. C., Langman, R. E., Paetkan, V. H., Diener, E.: Cell. Immunol.17, 405 (1975)
Makman, M. H., Dvoskin, B., White, A.: Proc. Nat. Acad. Sci.68, 1269 (1967)
Makman, M. H., Dvoskin, B., White, A.: J. Biol. Chem.241, 1646 (1966)
Makman, M. H., Nakagawa, S., Dvoskin, B., White, A.: J. Biol. Chem.245, 2556 (1970)
Malkiel, S., Hargis, B. J.: J. Immunol.69, 217 (1952)
Medawar, P. B., Sparrow, E. M.: J. Endocrinol.14, 240 (1956)
Mirick, G. S.: J. Clin. Invest.29, 836 (1950)
Meshalova, A. N., Fryazinova, I. B.: Zh. Mikrobiol. Epidemiol. Immunolbiol.31, 23 (1965)
Moeschlin, S., Baguena, R., Baguena, J.: Bull. Schweiz. Akad. Med.8, 153 (1953)
Moll, F. C., Hawn, C. Z.: J. Immunol.70, 441 (1953)
Morgan, J. A.: Surgery30, 506 (1951)
Morita, J., Munck, A.: Biochim. Biophys. Acta93, 150 (1964)
Mountain, I. M.: J. Immunol.74, 270 (1955)
Munck, A.: J. Biol. Chem.243, 1039 (1968)
Munck, A., Brinck-Johnson, T.: J. Biol. Chem.243, 5556 (1968)
Nakagawa, S., White, A.: J. Biol. Chem.245, 1448 (1970)
Newsom, S. E., Darrach, M.: Canad. J. Biochem. Physiol.33, 374 (1954)
Roberts, S., White, A.: Endocrinology48, 741 (1951)
Sands, H., Haynes, R. C.: Endocrinology86, 144 (1970)
Schrek, B.: Proc. Soc. Exp. Biol. Med.108, 1120 (1966)
Solomon, G. F.: Arch. Allergy35, 97 (1969)
Sparrow, E. M.: J. Endocrinol.9, 101 (1953)
Stass, H. P.: Thesis München 1972
Studer, A.: Z. Rheumaforsch.9, 337 (1950)
Vann, D. C.: Cell. Immunol.11, 11 (1974)
Vischer, T. L.: Immunol.23, 777 (1972)
Wahl, S. J., Altmann, L. C., Rosenstreich, D. L.: J. Immunol.115, 476 (1975)
Weisman, G., Thomas, L.: Rec. Progr. Hormone Res.20, 215 (1964)
Whitfield, J. F., McManus, J. P., Rixon, R. N.: Proc. Soc. Exp. Biol. Med.134, 1170 (1970)
Winter, D., Stender, H. S., Strauch, D., Diefenbach, H.: Z. Immunforsch.123, 105 (1962)
Wistar, R., Hildeman, W. H.: Science131, 159 (1960)
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Comsa, J., Leonhardt, H. Influence of the adrenal cortex on allograft rejections in rats. Res. Exp. Med. 175, 51–59 (1979). https://doi.org/10.1007/BF01851233
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DOI: https://doi.org/10.1007/BF01851233