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Exokrine Pankreasfunktion und Calciumhomöostase. Vergleichende tierexperimentelle Untersuchungen zur Wirkung von Parathormon, Vitamin D3, 25-Hydroxycholecalciferol, Dihydrotachysterin und Thyreocalcitonin

Exocrine pancreatic function and calcium balance. Experimental studies of the effect of parathyroid hormone, vitamin D3, 25-hydroxycholecalciferol, dihydrotachysterin und thyrocalcitonin

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Research in Experimental Medicine

Summary

The effect of the acute elevation of extracellular calcium concentration, of vitamin D3, 25-hydroxycholecalciferol, dihydrotachysterin, parathyroid hormone and of thyrocalcitonin on the exocrine function of the perfused cat pancreas was studied.

Elevation of the perfusate calcium concentration resulted in an initial increase in the enzyme and, occasionally, calcium concentration of the pancreatic juice, the flow rate and the secretion of magnesium and chloride were not very much altered. The application of vitamin D3 and 25-hydroxycholecalciferol elevated the stimulated (by acetylcholine or cholecystokinin-pancreocymin) protein and enzyme output (lipase, α-amylase). Parathyroid hormone and, especially, thyreocalcitonin inhibited the stimulated protein and enzyme secretion, volume and rate of the electrolyte secretion were not changed.

In states of calcium excess the stimulated protein output was decreased by both vitamin D3 and parathyroid hormone.

Zusammenfassung

Am isoliert perfundierten Pankreas der Katze wurde die Wirkung der akuten Erhöhung der extrazellulären Calciumkonzentration und des Vitamin D3, des 25-Hydroxycholecalciferols, des Dihydrotachysterins, des Parathormons und des Thyreocalcitonins auf die exokrine Pankreasfunktion untersucht.

Bei Erhöhung des Perfusatcalciumgehaltes trat initial eine kurzfristige und geringe Proteinausschüttung in den Pankreassaft ein, eine Calciummehrausscheidung wurde nicht regelmäßig beobachtet, die hydrokinetische Funktionskomponente änderte sich nicht. Parathormon und insbesondere Thyreocalcitonin hemmten die stimulierte Protein- und Enzymsekretion des Pankreas, Vitamin D3 und 25-Hydroxycholecalciferol steigerten sie leicht. Bei akutem Calciumexzess führte auch Vitamin D3 zu einer Hemmung der stimulierten Proteinsekretion, eine Änderung der Volumen- und Elektrolytausscheidung trat bei keiner Substanz ein.

Die Relevanz dieser Befunde für die Pathogenese der calcifizierenden Pankreatitis bei chronischer Hypercalcämie wurde diskutiert.

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Abbreviations

CCK-PZ:

Cholecystokinin-Pankreozymin

DHT:

Dihydrotachysterin

PTH:

Parathormon

TCT:

Thyreocalcitonin

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Authors and Affiliations

  1. Nephrologische Abteilung, Med. Univ.-Klinik, Josef-Schneider-Straße 2, D - 8700, Würzburg, Bundesrepublik Deutschland

    E. Heidbreder, P. Sieber & A. Heidland

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  1. E. Heidbreder
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  2. P. Sieber
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  3. A. Heidland
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Mit Unterstützung der Deutschen Forschungsgemeinschaft, SFB 92 "Biologie der Mundhöhle"

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Heidbreder, E., Sieber, P. & Heidland, A. Exokrine Pankreasfunktion und Calciumhomöostase. Vergleichende tierexperimentelle Untersuchungen zur Wirkung von Parathormon, Vitamin D3, 25-Hydroxycholecalciferol, Dihydrotachysterin und Thyreocalcitonin. Res. Exp. Med. 166, 147–163 (1975). https://doi.org/10.1007/BF01851181

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  • DOI: https://doi.org/10.1007/BF01851181

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