Childs Nervous System

, Volume 6, Issue 4, pp 186–189 | Cite as

Adjunctive treatment for recurrent childhood ependymoma of the IV ventricle: chemotherapy with CDDP and MCNU

  • M. Tamura
  • N. Ono
  • H. Kurihara
  • C. Ohye
  • M. Miyazaki
Original Papers

Abstract

The prognosis of recurrent IV-ventricle ependymoma in children is poor. Three cases of recurrent ependymoma were treated with combination chemotherapy usingcis-diamine dichloro platinum (II) (CDDP) and methyl-6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-α-d-glucopyranoside (MCNU). The patients were 2-, 3-, and 6-year-old boys. The interval between the first operation with irradiation and recurrence was 1 year and 5 months to 2 years. Two cases showed a recurrence at the original site; in the other case, a right sylvian tumor deposit was found via computed tomography. The therapeutic regimen for recurrnt ependymomas was as follows: (1) the tumor was debulked if possible; (2) additional local irradiation of 30 Gy was administered; (3) combined treatment of 100 mg/m2 CDDP and 80 mg/m2 MCNU over 24 h was given 5 times with an interval of 6 weeks between treatments. The patients tolerated the therapy well with only mild side effects. Remission lasted 1 year in two patients and has lasted for 8 months in one.

Key words

Cisplatin MCNU Chemotherapy Ependymoma Children 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Coulon RA, Till K (1977) Intracranial ependymoma in children. A review of 43 cases. Child's Brain 3:154–168PubMedGoogle Scholar
  2. 2.
    Dohrmann GJ, Farwell JR, Flannery JT (1976) Ependymoma and ependymoblastomas in children. J Neurosurg 45:273–283CrossRefPubMedGoogle Scholar
  3. 3.
    Harada K, Okamoto H, Fujioka Y, Uozumi T, Kiya K, Kitaoka T, Goishi A, Sasaki U, Shima T, Inagawa T, Kodama Y, Kuwabara S, Yoshimoto H, Nishimura S, Yamane K, Ohta N (1985) Clinical trial of MCNU to malignant brain tumors (in Japanese). Jpn J Cancer Chemother 12:1423–1431Google Scholar
  4. 4.
    Heiskanen O, Lehtosalo J (1985) Surgery of cerebellar astrocytomas, ependymomas and medulloblastomas in children. Acta Neurochir (Wien) 78:1–3CrossRefGoogle Scholar
  5. 5.
    Khan AB, D'Souza BJ, Wharam MD, Campion LAA, Sinks LF, Woo SY, McCullough DC, Leventhal BG (1982) Cisplatin therapy in recurrent childhood brain tumors. Cancer Treat Rep 66:2013–2020PubMedGoogle Scholar
  6. 6.
    Kun LE, Kovner EH, Sanford RA (1988) Ependymomas in children. Pediatr Neurosci 14:57–63CrossRefPubMedGoogle Scholar
  7. 7.
    Matson DD (1969) Neurosurgery of infancy and childhood, 2nd edn. Thomas, Springfield, IIIGoogle Scholar
  8. 8.
    Oi S, Raimondi AJ (1980) Brain tumors in infants and children. Factors affecting prognosis. I. Ependymoma (in Japanese). Neurol Surg 8:1049–1055Google Scholar
  9. 9.
    Rorke LB (1987) Relationship of morphology of ependymoma in children to prognosis. Prog Exp Tumor Res 30:170–174PubMedGoogle Scholar
  10. 10.
    Sexauer CL, Khan A, Burger PC, Krischer JP, Eys JV, Vats T, Ragab AH (1985) Cisplatin in recurrent pediatric brain tumors. A POG phase II study. A pediatric oncology group study. Cancer 56:1497–1501CrossRefPubMedGoogle Scholar
  11. 11.
    Wakabayashi T, Yoshida J, Kito A, Inoue I, Kobayashi T, Kageyama N (1984) Effect of MCNU on brain tumors. II. Clinical experience with MCNU on malignant brain tumors (in Japanese). Jpn J Cancer Chemother 11:2729–2737Google Scholar
  12. 12.
    Walker R, Allen JC (1988) Cisplatin in the treatment of recurrent childhood primary brain tumors. J Clin Oncol 6:62–66PubMedGoogle Scholar
  13. 13.
    West CR, Bruce DA, Duffner PK (1985) Ependymomas. Factors in clinical and diagnostic staging. Cancer 56:1812–1816CrossRefPubMedGoogle Scholar
  14. 14.
    Zülch KJ (1979) Histological typing of tumors of the central nervous system. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Tamura
    • 1
  • N. Ono
    • 1
  • H. Kurihara
    • 1
  • C. Ohye
    • 1
  • M. Miyazaki
    • 2
  1. 1.Department of NeurosurgeryGunma University School of MedicineShowa-machiJapan
  2. 2.Division of NeurosurgeryMaebashi Red Cross HospitalMaebashiJapan

Personalised recommendations