Childs Nervous System

, Volume 6, Issue 4, pp 186–189 | Cite as

Adjunctive treatment for recurrent childhood ependymoma of the IV ventricle: chemotherapy with CDDP and MCNU

  • M. Tamura
  • N. Ono
  • H. Kurihara
  • C. Ohye
  • M. Miyazaki
Original Papers


The prognosis of recurrent IV-ventricle ependymoma in children is poor. Three cases of recurrent ependymoma were treated with combination chemotherapy usingcis-diamine dichloro platinum (II) (CDDP) and methyl-6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-α-d-glucopyranoside (MCNU). The patients were 2-, 3-, and 6-year-old boys. The interval between the first operation with irradiation and recurrence was 1 year and 5 months to 2 years. Two cases showed a recurrence at the original site; in the other case, a right sylvian tumor deposit was found via computed tomography. The therapeutic regimen for recurrnt ependymomas was as follows: (1) the tumor was debulked if possible; (2) additional local irradiation of 30 Gy was administered; (3) combined treatment of 100 mg/m2 CDDP and 80 mg/m2 MCNU over 24 h was given 5 times with an interval of 6 weeks between treatments. The patients tolerated the therapy well with only mild side effects. Remission lasted 1 year in two patients and has lasted for 8 months in one.

Key words

Cisplatin MCNU Chemotherapy Ependymoma Children 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Tamura
    • 1
  • N. Ono
    • 1
  • H. Kurihara
    • 1
  • C. Ohye
    • 1
  • M. Miyazaki
    • 2
  1. 1.Department of NeurosurgeryGunma University School of MedicineShowa-machiJapan
  2. 2.Division of NeurosurgeryMaebashi Red Cross HospitalMaebashiJapan

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