Abstract
The study was undertaken to evaluate the effect of antifibrinolytic agents (ε-aminocaproic acid, EACA; tranexamic acid, AMCA), anti-inflammatory drugs (indomethacin, IND; ibuprofen, IBU; naproxen, NAP) and root extract of the plantBoerhaavia diffusa (BD) on menstrual cycle length (MCL), duration of menstrual flow (DMF), menstrual iron loss (MIL) and activity of uterine tissue plasminogen activator (tPA) in IUD-fitted monkeys. Premature onset of menstruation was observed in IUD-fitted monkeys (26.0±0.7 days, mean±SE) as compared to controls (28.7±0.4 days). No noteworthy change was observed in the MCL of drug treated monkeys as compared to IUD-fitted monkeys. An increase of 155%, 123.2%, and 288% was observed in the DMF, MIL and tPA activity after IUD insertion as compared to controls. Antifibrinolytic agents reduced the DMF, MIL and activity of tPA in IUD-fitted monkeys up to 117.4%, 116.4%, and 254%, whereas anti-inflammatory drugs caused a decrease only up to 69%, 95.1%, and 138%, respectively. Conclusively, root extract ofB. diffusa treated IUD-fitted monkeys showed noticeable reduction in their DMF (124%), MIL (120.8%) and tPA activity (272%).
Resumé
Une étude a été entreprise pour évaluer chez des guenons portant des dispositifs intra-utérins les effets d'agents antifribinolytiques (acide ε-aminocaproïque (EACA); acide tranexamique (AMCA), de médications anti-inflammatoires (indométhacine (IND), ibuprofen (IBU), naproxen (NAP)) et de l'extrait de racine deBoerhavia diffusa (BD); l'étude a porté sur la ongueur du cycle menstruel (MCL), la durée du flux menstruel (DMF), la perte ferrique due à la menstruation (MIL) et de l'activation du plasminogène du tissu utérin (tPA). On a observé un déclenchement prématuré de la menstruation chez les guenons portant les DIU (26,0±0,7 jours, moyenne±E.M.) par comparaison avec un groupe témoin (28,7±0,4 jours). Aucun changement notable de la longueur du cycle menstruel n'a été constaté constaté chez les guenons observant les médications par comparaison avec celles qui portaient un DIU. On a observé une augmentation de la durée du flux menstruel (155%), de la perte ferrique (123,2%) et de l'activation du plasminogène (288%) après l'insertion du DIU par comparaison avec le groupe témoin. Les agents antifibrinolytiques ont eu pour effet de diminuer, chez les guenons portant un DIU, la durée du flux menstruel, la perte ferrique et l'activation du plasminogène, dans des proportions allant jusqu'à 117,4%, 116,4% et 254% respectivement, alors que les anti-inflammatoires ont entraîné une diminution n'allant que jusqu'à 69%, 95,1% et 138% respectivement. Chez les guenons portant un DIU et traitées à l'extrait de racine de BD, on a observé de façon concluante une réduction sensible de la durée du flux menstruel (124%), de la perte ferrique (120,8%) et de l'activation du plasminogène (272%).
Resumen
Se realizó un estudio para evaluar en monas con dispositivos intrauterinos los efectos de agentes antifibrinolíticos (ácido ε-aminocaproico (EACA), ácido tranexámico (AMCA), medicamentos antiinflamatorios (indometacina (IND), ibuprofen (IBU), naproxen (NAP) y del extracto de raíz deBoerhavia diffusa (BD) sobre la duración del ciclo menstrual (MCL), la duración del flujo menstrual (DMF), la pérdida de hierro a causa de la menstruación (MIL) y la activación del plasminógeno del tejido uterion (tPA). Se observó el desencadenamiento prematuro de la menstruación en las monas con DIU (26,0±0,7 días, media±E.M.) en comparación con un grupo testigo (28,7±0,4 días). No se observó ningún cambio notable en la duración del ciclo menstrual en las monas tratadas con medicamentos en comparación con las que tenían un DIU. Se observó un aumento de la duración del flujo menstrual (155%), de la pérdida de hierro (123,2%) y de la activación del plasminógen (288%) después de la colocación del DIU en comparación con el grupo testigo. El efecto de los agentes antifibrinolíticos fue disminuir, en las monas con DIU, la duración del flujo menstrual, la pérdida de hierro y la activación del plasminógeno, en proporciones que iban hasta el 117,4%, 116,4% y 254%, respectivamente, mientras que los medicamentos antiinflamatorios provocaron una disminución que iba sólo hasta el 69%, 95,1% y 138%, respectivamente. En las monas con DIU y tratadas con el extracto de raíz de BD, se observó en forma concluyente una reducción notable de la duración del flujo menstrual (124%), de la pérdida de hierro (120,8%) y de la activación del plasminógeno (272%).
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Barthwal, M., Srivastava, K. Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta). Adv Contracept 7, 67–76 (1991). https://doi.org/10.1007/BF01850720
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DOI: https://doi.org/10.1007/BF01850720