Advances in Contraception

, Volume 7, Issue 1, pp 1–9 | Cite as

Histopathologic changes in the cornual portion of the fallopian tube following a single transcervical insertion of quinacrine hydrochloride pellets

  • A. A. El-Kady
  • M. M. Mansy
  • H. S. Nagib
  • E. Kessel
Article

Abstract

To study the sequence of histopathologic changes taking place in the cornual portion of the fallopian tube subsequent to exposure to quinacrine, 252 mg were inserted transcervically in 12 women awaiting hysterectomy for non-malignant conditions of the uterus. All patients who underwent surgery within ten days of insertion were found to have necrosis of the epithelial lining and an acute inflammatory reaction. Later on, the changes observed included progressive absorption of the inflammatory cellular exudate, progressive fibrosis, with partial or almost complete occlusion of the lumen, and failure of regeneration of the epithelial lining. Our results support other studies indicating that quinacrine can effectively produce tubal fibrosis and occlusion.

Keywords

Public Health Inflammatory Reaction Fallopian Tube Histopathologic Change Complete Occlusion 

Resumé

Pour étudier la succession des changements histopathologiques qui se produisent dans la portion cornée de la trompe de Fallope après une exposition à la quinacrine, on a inséré par le col utérin 252 mg de cette substance chez 12 femmes qui devaient subir une hystérectomie pour des raisons autres que des tumeurs malignes. On a constaté chez toutes les patientes opérées dans les dix jours suivant l'insertion une nécrose de la bordure épithéliale et une réaction inflammatoire aigüe. Ultérieurement, les changements observés comprenaient la résorption progressive de l'exudat cellulaire inflammatoire, une fibrose progressive avec occlusion partielle ou presque totale de la cavité et une absence de régénération de la couche ópithéliale. Nos résultats viennent à l'appui d'autres études indiquant que la quinacrine peut effectivement produire la fibrose et l'occlusion des trompes.

Resumen

Para estudiar la sucesión de cambios histopatológicos que se producen en la porción córnea de la trompa de Falopio después de la exposición a la quinacrina, se insertaron por el cuello del útero 252 mg de esta sustancia en 12 mujeres a las que se les practicaría una histerectomía por motivos que no eran los de tumores malignos. Se verificó en todas las pacientes operadas dentro de los diez días posteriores a la inserción una necrosis del revestimiento epitelial y una reacción inflamatoria aguda. Posteriormente, los cambios observados comprendieron la reabsorción progresiva del exudado celular inflamatorio, una fibrosis progresiva con oclusión parcial o casi total de la cavidad y la falta de regeneración de la capa epitelial. Nuestros resultados apoyan otros estudios que indican que la quinacrina puede efectivamente producir fibrosis y oclusión de las trompas.

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References

  1. 1.
    ZipperJ., StachettiE. and MedelM. (1970). Human fertility control by transvaginal application of quinacrine on the fallopian tube.Fertil. Steril.,21, 581–589PubMedGoogle Scholar
  2. 2.
    BenoitA., MelanconJ. and GagnonM. (1975). Chemically induced tubal occlusion in the human female using intrauterine instillation of quinacrine.Contraception,12, 95–101PubMedGoogle Scholar
  3. 3.
    ZipperJ., MedelM., GoldsmithA., EdelmanD., PasteneL. and RiveraM. (1976). The clinical efficacy of the repeated transcervical instillation of quinacrine for female sterilization.Int. J. Gynecol. Obstet.,14, 499–502Google Scholar
  4. 4.
    IsrangkunC., PhaosavadiS., NeuwirthR.S. and RichartR.M. (1976). Clinical evaluation of quinacrine hydrochloride for sterilization of the human female.Contraception,14, 75–80PubMedGoogle Scholar
  5. 5.
    ZipperJ., ColeL.P., GoldsmithA., WheelerR. and RiveraM. (1980). Quinacrine hydrochloride pellets: preliminary data on a non-surgical method of female sterilization.Int. J. Gynecol. Obstet.,18, 275–279Google Scholar
  6. 6.
    Guzman-SeraniR., BernalesA. and ColeL.P. (1983). Quinacrine hydrochloride pellets: three-year follow-up on a non-surgical method of female sterilization.Contracept. Deliv. Syst.,5, 131–135Google Scholar
  7. 7.
    DavidsonO. and WilkinsC. (1973). Chemically induced tubal occlusion in the human female following a single instillation of quinacrine.Contraception,7, 333–339Google Scholar
  8. 8.
    BhattR.V., AparicioA., LaufeL.E., ParmleyT. and KingT.M. (1980). Quinacrine-induced pathologic changes in the fallopian tube.Fertil. Steril.,33, 666–667PubMedGoogle Scholar
  9. 9.
    MerchantR.N., DoctorV.M., ThakuS.S., SinhaM., JharveriC.L., KesselE. and MumfordS.D. (1986). Clinico-pathological study of fallopian tubes after transcervical insertion of quinacrine hydrochlorid pellets.Adv. Contracept.,2, 79–90PubMedGoogle Scholar
  10. 10.
    KesselE. (1989). Prospects for nonsurgical female sterilization.Int. J. Gynecol. Obstet.,29, 1–4Google Scholar
  11. 11.
    KesselE., ZipperJ. and MumfordS.D. (1985). Quinacrine non-surgical female sterilization: a reassessment of safety and efficacy.Fertil. Steril.,44, 293–298PubMedGoogle Scholar
  12. 12.
    ZipperJ., ColeL.P., RiveraM., BrownE. and WheelerR.G. (1987). Efficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization.Adv. Contracept.,3, 255–261PubMedGoogle Scholar
  13. 13.
    Mullick, B. (1990). Personal communication.Google Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • A. A. El-Kady
    • 1
  • M. M. Mansy
    • 2
  • H. S. Nagib
    • 1
  • E. Kessel
    • 3
  1. 1.Department of Obstetrics and GynecologyBoulak El-Dakrour HospitalGizaEgypt
  2. 2.Lecturer in Pathology, Kasr El-Aini Faculty of MedicineCairo UniversityEgypt
  3. 3.Department of Public Health and Preventive MedicineOregon Health Sciences UniversityPortland

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