Abstract
A comparative study was made of four intrauterine contraceptive devices: the Nova-T, MLCu250 Short, MLCu375, and the Gyne T. An endometrial biopsy was performed on the 25th day of the menstrual cycle. The tissue obtained was analyzed to determine estrogen and progesterone receptor concentration. After two years of IUD use, both estrogen and progesterone receptors decreased proportionally to the increased amount of copper in the IUD.
Resumé
Une étude comparative a été effectuée sur quatre dispositifs de contraception intrautérins: les Nova-T, MLCu250 ‘Short’, MLCu375 et Gyne T. Une biopsie endométriale a été pratiquée au vingt-cinquième jour du cycle menstruel. L'échantillon obtenu a été analysé afin de déterminer la concentration des récepteurs d'oestrogène et de progestérone. près deux années d'utilisation des DIU, les récepteurs aussi bien d'oestrogène que de progestérone avaient diminué proportionnellement à l'augmentation de la teneur en cuivre du dispositif.
Resumen
Se efectuó un estudio comparativo de cuatro dispositivos anticonceptivos: el Nova-T, MLCu250 ‘Short’ MLCu375 y el Gyne T. Se hizo una biopsia endometrial en el día 25 del ciclo menstrual. El tejido así obtenido fué analizado para determinar la concentración de receptores de estrógeno y progesterona. Después de dos años de uso de los DIU, estos receptores disminuyeron proporcionalmente al aumento de cobre en el DIU.
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de Castro, A., Gonzalez-Gancedo, P. Mechanism of action of high-load copper IUDs. Adv Contracept 4, 185–190 (1988). https://doi.org/10.1007/BF01849436
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DOI: https://doi.org/10.1007/BF01849436