Advances in Contraception

, Volume 2, Issue 1, pp 79–90 | Cite as

Clinico-pathological study of Fallopian tubes after transcervical insertion of quinacrine hydrochloride pellets

  • R. N. Merchant
  • V. M. Doctor
  • S. S. Thaku
  • M. Sinha
  • C. L. Jhaveri
  • E. Kessel
  • S. D. Mumford
Article

Abstract

This study lends support to others indicating the apparent safety and effectiveness of multiple transcervical insertions of quinacrine hydrochloride as pellets in 240 mg dosage to achieve permanent sterilization. In order to study the effects of the number of quinacrine pellet insertions and the site of placement of the pellets in the uterus of prehysterectomy volunteers, a scoring system of histological changes in the Fallopian tube was designed. Quinacrine pellets were deposited at the fundus using a straight inserter in 16 women, and at the cornua using a curved inserter in 17 women. Each group had at least five women receiving one, two or three insertions at one-week intervals. Results indicate that neither the number of insertions nor the place of deposition of the pellets affects the degree of tubal inflammation and fibrosis.

Keywords

Public Health Histological Change Fallopian Tube Quinacrine Tubal Inflammation 

Résumé

Cette étude vient appuyer d'autres recherches qui ont indiqué la sécurité et l'efficacité apparentes d'insertions transcervicales multiples de doses de 240 mg d'hydrochlorure de quinacrine en pillules pour obtenir une stérilisation. Pour étudier les effets d'un certain nombre d'insertions de pillules de quinacrine et d'insertions de pillules dans l'utérus de volontaires en pré-hystérectomie, un système de comptage des points a été conçu pour noter les changements hystologiques dans la trompe de Fallope. Des pillules de quinacrine ont été placées au fond de l'utérus de 16 femmes à l'aide d'un tube d'insertion droit et dans le col de 17 femmes à l'aide d'un tube d'insertion recourbé. Dans chaque groupe, au moins 5 femmes ont reçu une, deux ou trois insertions à une semaine d'intervalle. Les résultats indiquent que le nombre d'insertions et le point d'insertion de ces pillules n'ont aucun effet sur le taux d'incidence des inflammations des trompes et de fibroses.

Resumen

Este estudio corrobora las conclusiones de otros autores indicando la aparente inocuidad y efectividad de múltiples inserciones transcervicales de ‘pellets’ de hidroclorato de quinacrina de 240 mg, a efecto de establecer una esterilización permanente. A fin de estudiar los efectos del número de inserciones de ‘pellets’ de quinacrina y el lugar de su emplazamiento en el útero, se estableció un sistema de puntaje para evaluar los cambios histológicos en la trompa de Fallopio en mujeres que iban a ser histerectomizadas. Los ‘pellets’ de quinacrina fueron depositados en el fondo del útero utilizando un insertor recto en 16 mujeres; y a nivel de los cuernos uterinos utilizando un insertador curvo en 17 mujeres. Cada grupo tuvo no menos de 5 mujeres con una, dos o tres inserciones semanales. Los resultados indican que ni el número de inserciones ni el lugar de emplazamiento de los ‘pellets’ afecta el grado de inflamación y fibrosis tubaria.

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Copyright information

© MTP Press Ltd 1986

Authors and Affiliations

  • R. N. Merchant
    • 1
    • 2
  • V. M. Doctor
    • 3
  • S. S. Thaku
    • 1
    • 2
  • M. Sinha
    • 3
  • C. L. Jhaveri
    • 4
  • E. Kessel
    • 5
  • S. D. Mumford
    • 6
  1. 1.B. Y. L. Nair HospitalBombayIndia
  2. 2.T. N. Medical CollegeBombayIndia
  3. 3.Breach Candy HospitalBombayIndia
  4. 4.Indian Fertility Research ProgrammeBombayIndia
  5. 5.International Federation for Family HealthChapel HillUSA
  6. 6.Center for Research on Population and SecurityResearch Triangle ParkNorth CarolinaUSA

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