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The Ljubljana IUDS: further observations on surface morphology

Abstract

Twelve IUDs that had been worn from 8 years 10 months to 24 years were examined by SEM. Photomicrographs of selected samples are shown, and a discussion of the nature of the surface encrustations is provided. The authors are of the opinion that surface encrustations are generic to different types of IUDs and that their clinical significance is presently unknown.

Résumé

Douze stérilets qui ont été utilisés pendant une période allant de 8 ans et 10 mois à 24 ans ont fait ĺobject 'dun examen sous microscope électronique. Des microphotographies de spécimens sélectionnés illustrent ce document. Après avoir examiné la nature des incrustations superficielles, les auterus en ont tiré la conclusion que les différents types de stérilets présentent tous les mêmes incrustations dont on ne connaît pas encore la signification clinique.

Resumen

Doce DIU que fueron usados de 8 años 10 meses a 24 años, se examinaron por microscopio de barrido. Se muestran microfotografías de especímenes seleccionados y se especula sobre la naturaleza de las incrustaciones en la superficie. Los autores son de opinión que las incrustaciones en la superficie son comunes para los distintos tipos de DIU y que actualmente se desconoce su significado clínico.

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References

  1. PottsM. and PearsonR. M. (1967). A light and electron microscope study of cells in contact with intrauterine contraceptive devices.J. Obstet. Gynaecol. Br. Commonw.,74, 129

    PubMed  Google Scholar 

  2. EngineerA. D., DasGuptaP. R. and KarA. B. (1970). Chemical composition of the deposit formed on the Lippes Loop after prolonged use.Am. J. Obstet. Gynecol.,106 325

    PubMed  Google Scholar 

  3. JohnsonA. B., ManessR. F. and WheelerR. G. (1976). Calcareous deposits formed on IUDs in human exposures.Contraception,14, 507

    PubMed  Google Scholar 

  4. VanEyckJ., LagasseA. and ThieryM. (1976). Scanning electron microscopy of inert and copper-bearing intrauterine devices.Contraception,13, 65

    PubMed  Google Scholar 

  5. GosdenC., RossA. and LoudonN. (1977). Intrauterine deposition of calcium on copper-bearing intrauterine devices.Brit. Med. J.,1, 202

    PubMed  Google Scholar 

  6. BankH. (1977). Scanning electron microscopy of copper containing intrauterine devices: Long term changesin utero.Fertil. Steril.,26, 503

    Google Scholar 

  7. SheppardB. L. and BonnarJ. (1980). Scanning and transmission electron microscopy of material adherent to intrauterine contraceptive devices.Brit. J. Obstet. Gynaecol.,87, 155

    Google Scholar 

  8. GonzalezE. (1981). Calcium deposits on IUDs may play role in infections.J. Am. Med. Assoc.,245, 1695

    Google Scholar 

  9. RosenfieldJ., WilliamsW. S. and SharmaN. K. (1981). SEM analysis of copper-containing intrauterine implants.J. Biomed. Mater. Res.,15, 605

    PubMed  Google Scholar 

  10. SchmidtW. (1982). IUDs, inflammation and infection: Assessment after two decades of IUD use.Hum. Pathol.,13, 878

    PubMed  Google Scholar 

  11. MarrieT. J. and CostertonJ. W. (1983). A scanning and transmission electron microscopic study of the surfaces of intrauterine contraceptive devices.Am. J. Obstet. Gynecol.,146, 384

    PubMed  Google Scholar 

  12. KeithL., BaileyR. and BergerG. S. (1985). Surface changes in intrauterine contraceptive devices after variable use.Am. J. Obstet. Gynecol.,152, 69

    PubMed  Google Scholar 

  13. KeithL. G., BaileyR. and BergerG. S. (1985). Morphologic changes on the surface of IUDs: Are they of clinical significance? In:Future Aspects in Contraception. II. Female Contraception, B.Runnenbaum, T.Rabe and L.Kiesel, eds., MTP Press, Lancaster, UK, pp. 203–228

    Google Scholar 

  14. KeithL. G. and BaileyR. (1985). Energy dispersive spectrophotometric and X-ray diffraction observations in IUDs.Adv. Contracept.,1, 171

    PubMed  Google Scholar 

  15. GuptaP. K. (1982). Intrauterine contraceptive devices-vaginal cytology, pathologic changes and clinical implications.Acta Cytol.,26, 571

    PubMed  Google Scholar 

  16. AndolšekL., KožuhM. and BaloghS. A. (1984). Long term use of non-medicated IUDs in women over forty. In: G. I.Zatuchni, A.Goldsmith and J. J.Sciarra, eds.,Intrauterine Contraception: Advances and Future Prospects. PARFR Series on Fertility Regulation, Harper & Row, Philadelphia, pp. 375–386

    Google Scholar 

  17. PataiVonK. and BerenyiM. (1982). Inkrustatbildung auf intrauterinen Empfängnis-verhutern.Zbl. Gynäkol.,104, 1385

    Google Scholar 

  18. PataiVonK. (1984). Kalciumhaltige enkrustationsformen auf IUD-Elektronon-mikroscopischer Scan-Nachweis.Zbl. Gynäkol.,106, 403

    Google Scholar 

  19. NancallasG. H. and MohanM. S. (1970). The growth of hydroxy apatite crystals.Arch. Oral Biol.,15, 731

    PubMed  Google Scholar 

  20. MeyerJ. L., EickJ. D., NancallasG. H. and JohnsonL. N. (1972). A scanning electron microscopic study of the growth of hydroxy-apatite crystals.Calcium Tissue Res.,10, 91

    Google Scholar 

  21. JensenA. T. and DanoM. (1954). Crystallography of dental calculus and the precipitation of certain calcium phosphates.J. Dent. Res.,33, 741

    PubMed  Google Scholar 

  22. WassermanB. H., MandelI. D. and LenyB. M. (1958).In vitro calcification of dental calculus.J. Periodontol.,29, 144

    Google Scholar 

  23. MarcusZ. H., DonderoF., LunenfeldB. and LewinL. M. (1985). Effect of the inhibitory material from male genital tract on natural killing activities.Immunol. Lett.,10, 1

    PubMed  Google Scholar 

  24. WinklerK. C. and DirksO. B. (1958). The mechanism of dental plaque.Int. Dent. J.,8, 561

    Google Scholar 

  25. RitzH. L. (1976). Microbial population shifts in developing human dental plaque.Arch. Oral Biol.,12, 1561

    Google Scholar 

  26. GibbonsR. J. and VanHauteJ. (1973). On the formation of dental plaques.J. Periodontol,44, 347

    PubMed  Google Scholar 

  27. RizzoA. A., ScottD. B. and BladenH. A. (1963). Calcification of oral bacteria.Ann. NY Acad. Sci.,109, 14

    PubMed  Google Scholar 

  28. ZanderH. A., HazenS. P. and ScottD. B. (1986). Mineralization of dental calculus.Proc. Soc. Exp. Biol. Med.,103, 257

    Google Scholar 

  29. KeithL. G., BergerG. S. and Lopez-ZenoJ. (1986).New concepts on the causation of pelvic inflammatory disease, Year Book Medical Publishers, Chicago

    Google Scholar 

  30. KeithL. G., BergerG. S., EdelmanD. A., NewtonW., BaileyR. and FribergJ. (1984). On the causation of pelvic inflammatory disease.Am. J. Obstet. Gynecol.,149, 215

    PubMed  Google Scholar 

  31. EdelmanD. A., BergerG. S. and KeithL. G. (1982). The use of IUDs and their relationship to pelvic inflammatory disease: A review of epidemiologic and clinical studies.Current Problems in Obstetrics and Gynecology, vol. V, no. 3, Year Book Medical Publishers, Chicago

    Google Scholar 

  32. DeFoortP. (1985). An appraisal of the risk of IUD-related genital infections. In: G. I.Zatuchni, A.Goldsmith and J. J.Sciarra, eds.,Intrauterine Contraception: Advances and Future Prospects. PARFR Series on Fertility Regulation, Harper & Row, Philadelphia, pp. 390–397

    Google Scholar 

  33. HofstadterD. R. (1982). Default assumptions.Sci. Am.,247, 14 (cited in ref. 32)

    Google Scholar 

  34. NewtonW. and KeithL. G. (1985). Role of sexual behavior in the development of pelvic inflammatory disease.J. Reprod. Med.,30, 82

    PubMed  Google Scholar 

  35. MishellD. R., BellJ. H., GoodR. G. and MoyerD. L. (1966). The intrauterine device: A bacteriologic study of the endometrial cavity.Am. J. Obstet. Gynecol.,96, 119

    PubMed  Google Scholar 

  36. JephcottA. E., ReyunA. and Birch-AndersonA. (1971).Neisseria gonorrhoeae: III. Demonstration of presumed appendages to cells from different colony types.Acta Pathol. Microbiol. Scand.,79, 437

    Google Scholar 

  37. James-HolmquestA. N., SwansonJ., BuchananT. M., WendeR. D. and WilliamsR. P. (1974). Differential attachment of piliated and non-piliatedNeisseria gonorrhoeae to human sperm.Infect. Immunol.,9, 897

    Google Scholar 

  38. BuchananT. M. and PearceW. A. (1976). Pili as a mediator of the attachment of gonococci to human erythrocytes.Infect. Immunol.,13, 1483

    Google Scholar 

  39. HodgkissW., ShortJ. A. and WalkerP. D. (1976). Bacterial surface structures. In: R.Fuller and D. W.Lovelock, eds.,Microbial Ultrastructure. The Society for Applied Bacteriology Technical Series, No. 10, Academic Press, New York, pp. 49–72

    Google Scholar 

  40. HighsmithA. K. and JarvisW. R. (1985).Klebsiella pneumoniae: Selected virulence factors that contribute to pathogenicity.Infect. Control,6, 75

    PubMed  Google Scholar 

  41. FletcherM. and FloodgateG. D. (1976). The adhesion of bacteria to solid surfaces. In: R.Fuller and D. W.Lovelock, eds.,Microbial Ultrastructures, Academic Press, London, pp. 101–107

    Google Scholar 

  42. Costerton, J. W., Irvin, R. T. and Cheng, K. J. (1981). The role of bacterial surface structures in pathogenesis.CRC Critical Reviews in Microbiology, Sept. 1981, pp. 303–338

  43. GeeseyG. G., RichardsonW. T., YeomansH. G., IrvinR. T. and CostertonJ. W. (1977). Microscopic examination of natural sessile bacterial populations from an alpine stream.Can. J. Microbiol.,23, 1733

    PubMed  Google Scholar 

  44. TatumH. J., SchmidtF. H. and PhillipsD. M. (1975) The Dalkon Shield controversy; Structural and bacteriological studies of IUD tails.J. Am. Med. Assoc.,231, 711

    Google Scholar 

  45. PurrierB. G. A., SparksR. A., WattP. J. and ElsteinM. (1979).In vitro study of the possible role of the intrauterine contraceptive device tail in ascending infection of the genital tract.Br. J. Obstet. Gynaecol.,86, 374

    PubMed  Google Scholar 

  46. Morgos, F. W., Hillen, N. D. and Gosling, P. J. (1984). Colonization of IUD tails. Book of Abstracts, No. 71,International Symposium, Future Aspects in Contraception, Sept. 5–8, 1984, Heidelberg, West Germany

  47. BankH. L. and WilliamsonH. O. (1983). Scanning electron microscopy of Dalkon Shield tails.Fertil. Steril.,40, 334

    PubMed  Google Scholar 

  48. Population reports. (1984). IUDs: An appropriate contraceptive for many women.Population Information Program, Series B, No. 4, The Johns Hopkins University, Baltimore, USA

  49. Kurz, K. (1983, 1984). Personal communications

  50. FaveroM. S. (1982). Iodine-Champagne in a tin cup.Infect. Control,3, 30 (editorial)

    PubMed  Google Scholar 

  51. SautterR. L., MattmanL. H. and LegaspiR. C. (1984).Serratia Marcescens meningitis associated with a contaminated Benzalkonium chloride solution.Infect. Control,5, 223

    PubMed  Google Scholar 

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Keith, L.G., Bailey, R. & Method, M. The Ljubljana IUDS: further observations on surface morphology. Adv Contracept 2, 37–54 (1986). https://doi.org/10.1007/BF01849296

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Keywords

  • Public Health
  • Clinical Significance
  • Surface Morphology
  • Surface Encrustation