Abstract
The effects of a single administration of authentic prostaglandin A1 intravaginally in early pregnant hamsters were investigated. A single dose of 1 mcg/animal given on day 4 of pregnancy inhibited the appearance of embryonic swellings when observed on day 8 of pregnancy. A significant fall (p<0.01) in FSH with a rise (p<0.03) in prolactin concentration in the serum and no change in LH levels were observed. The pituitary content of prolactin showed a significant decrease (p<0.0006) with no change in FSH and LH contents.
Progesterone concentration in the serum was markedly reduced (p<0.002), along with that of the ovaries (p<0.01). The decline in progesterone concentration coincided with the absence of corpora lutea and the embryos. However, no change in ovarian weights was observed. These results indicate the contragestive potential of prostaglandin A1. It appears to act as a luteolytic agent by disrupting the luteotropic complex (FSH:prolactin ratio).
Resumé
On a étudié les effets de l'administration par voie intravaginale d'une dose unique de prostaglandine A1 à des hamsters au début de la gestation. On a constaté au huitième jour qu'une dose unique de 1 mcg par animal, administrée au quatrième jour de gestation, avait inhibé l'apparition des grosseurs embryonnaires. On a constaté en outre une baisse significative (p<0,01) de l'HSF, avec une augmentation (p<0,03) de la concentration de prolactine sérique, mais aucun changement dans les niveaux de l'HL. La teneur en prolactine retrouvée dans l'hypophyse présentait une biasse significative (p<0,0006), sans qu'il y ait eu de changement dans la teneur en HSF et HL. En outre, la concentration de progestérone dans le sérum et dans les ovaires était sensiblement réduite (respectivementp<0,002 etp<0,01). La baisse de la concentration de progestérone concidait avec l'absence de corps jaune et d'embryon. Aucune modification du poids des ovaires n'a cependant été observée. Ces résultats font apparaitre le potentiel de la prostagladine A1 en tant qu'agent inhibiteur de la gestation. Son action semble être celle d'un agent lutéolytique qui perturbe le complexe lutéotrope. (HSF: proportion de prolactine)
Resumen
Se investigaron los efectos de una administración intravaginal de prostaglandina A1 en hamsters con embarazo temprano. Una sola dosis de 1 mcg/animal al 4° día del embarazo (P) inhibió la aparición de los edemas embriónicos cuando se los observó en el 8° día del embarazo. Se notó una caída significativa (p<0,01) en FSH con un aumento (p<0,03) en la concentración de prolactina y ningun cambio en los niveles de LH. E1 contenido de prolactina en la pituitaria mostró una disminución significativa (p<0,0006) sin cambios en los niveles de FSH y LH.
La concentración de progesterona en suero estuvo notablemente reducida (p<0,002) asi como la de los ovarios (p<0,01). La disminución en la concentración de progesterona coincidió con la ausencia de cuerpo lúteo y de embriones. Sin embargo, no se observó cambio en el peso ovárico. Estos resultados indican el potencial antigestante de la prostaglandina A1. Esta parece actuar como agente luteolítico, interrumpiendo el complejo luteotrópico (relación FSH:prolactina).
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Roy, R., Karanth, S., Dutt, A. et al. Involvement of prostaglandin A1 in interrupting early pregnancy in Syrian golden hamsters. Adv Contracept 3, 341–348 (1987). https://doi.org/10.1007/BF01849292
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DOI: https://doi.org/10.1007/BF01849292