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Amplification and detection of the VNTR locus D4S95 in a Japanese population

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Abstract

The D4S95-VNTR locus was amplified and the polymorphism analysed in a population sample of 169 randomly selected Japanese individuals. A total of 14 alleles containing 850–1360 base pairs were distinguished by agarose gel electrophoresis. The distribution of alleles was symmetrical with respect to one peak at 1030 bp. The mean exclusion chance and discrimination power were calculated as 0.604 and 0.876 respectively.

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References

  • Allitto BA, Horn GT, Altherr MR, Richard B, McClatchey AI, Wasmuth JJ, Gusella JF (1991) Detection by PCR of the VNTR polymorphism at D4S95. Nucleic Acids Res 19:4015

    Google Scholar 

  • Allitto BA, McClatchey AI, Barnes G, Altherr M, Wasmuth J, Frischauf AM, MacDonald ME, Gusella J (1992) Assay by polymerase chain reaction (PCR) of multi-allele polymorphisms in the Huntington's disease region of chromosome 4. Mol Cell Probes 6:513–520

    PubMed  Google Scholar 

  • Maniatis T, Frisch EF, Sambrook J (1982) Molecular cloning, Laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

    Google Scholar 

  • Norremolle A, Sorensen SA, Arctander P (1992) Nucleotide sequence and PCR-amplification of a polymorphic Mbo I site in human DNA marker D4S95 linked to the Huntington's disease locus. Clin Genet 42:210–211

    PubMed  Google Scholar 

  • Wasmuth JJ, Hewitt J, Smith B, Allard D, Haines JL, Skarecky D, Partlow E, Hayden MR (1988) A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature 332: 734–736

    PubMed  Google Scholar 

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Honda, K., Nakatome, M., Islam, M.N. et al. Amplification and detection of the VNTR locus D4S95 in a Japanese population. Int J Leg Med 108, 43–44 (1995). https://doi.org/10.1007/BF01845617

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  • DOI: https://doi.org/10.1007/BF01845617

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