Abstract
A spectrum of lymphomas, sarcomas, and carcinomas were tested for F1 hybrid resistance after s.c. inoculation of small numbers of cells into syngeneic and F1 hybrid mice. Significant F1 resistance was demonstrated against all tumors tested except one. Backcross and/or congenic inoculation tests showed significantH-2 linkage of hybrid resistance against all lymphomas and leukemias tested. There was no linkage betweenH-2 and hybrid resistance within the more limited group of carcinomas and sarcomas. DifferentH-2-linked resistance genes were shown to act against different lymphomas, including some that were induced by the same agent. Some lymphomas induced by different agents in the same strain were also found to differ in their sensitivity to the sameH-2-linked resistance factor. These data suggest the existence of a polymorphic system, probably pseudoallelic, rather than simply allelic in nature.
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Clark, E.A., Harmon, R.C., and Wicker, L.S.: Resistanceof H-2 heterozygous mice to parental tumors. II. Characterization of Hh-1-controlled hybrid resistance to syngeneic fibrosarcomas and EL-4 lymphoma.J. Immunol. 119:648–656, 1978
Cudkowicz, G. and Stimpfling, I.H.: Deficient growth of C57BL marrow cells transplanted in F1 hybrid mice.Immunology 7:291, 1964
Friberg, S., Jr.: Comparison of an immunoresistant and an immunosusceptible ascites subline from murine tumor TA3. I. Transplantability, morphology, and some physiochemical characteristics.J. Natl. Cancer Inst. 48:1463–1476, 1972
Harmon, R.C., Clark, E.A., O'Toole, C., and Wicker, L.S.: Resistance ofH-2 heterozygous mice to parental tumors. I. Hybrid resistance and natural cytotoxicity to EL-4 are controlled by theH-2 D Hh-1 region.Immunogenetics 4:601–607, 1977
Hellström, K.E.: Differential behavior of transplanted mouse lymphoma lines in genetically compatible homozygous and F1 hybrid mice.Nature 199:614
Kiessling, R., Petrányi, G., Klein, G., and Wigzell H.: Genetic variation ofin vitro cytolytic activity andin vivo rejection potential of non-immunized semi-syngeneic mice against a mouse lymphoma line.Int. J. Cancer 15:933–940, 1975
Klein, G. and Klein, E.: Histocompatibility changes in tumors.Comp. Physiol. 52, 1:125–168, 1958
Klein, G.O., Klein, G., Kiessling, R., and Kärre, K.:H-2-associated control of natural cytotoxicity and hybrid resistance against RBL-5.Immunogenetics 6:561–569, 1978
Oth, D., Donner, M., and Burg, C.: Measurement of the antitumoral immune reactions against a strain-specific chemically induced sarcoma in syngeneic and F1 hybrid mice.Eur. J. Cancer 7:479–482, 1971
Petrányi, G.G., Kiessling, R., Povey, S., Klein, G., Herzenberg, L., and Wigzell, H.: The genetic control of natural killer cell activity and its association with in vivo resistance against a Moloney lymphoma isograft.Immunogenetics 3:15–28, 1976
Snell, G.D.: Recognition structures determined by the H-2 complex.Transplant. Proc. 8:147–156, 1976
Snell, G.D. and Stevens, L.C.: Histocompatibility genes of mice III. H-1 and H-4, two histocompatibility loci in the first linkage group.Immunology 4:366–379, 1961
Williams, R.M., Dorf, M.E., and Benacerraf, B.: H-2 linked genetic control of resistance to histocompatibility tumors.Cancer Res. 35:1586–1590, 1975
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Klein, G., Klein, G.O., Kärre, K. et al. ‘Hybrid resistance’ against parental tumors: One or several genetic patterns?. Immunogenetics 7, 391–404 (1978). https://doi.org/10.1007/BF01844030
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DOI: https://doi.org/10.1007/BF01844030