Abstract
Serological studies relating F9 antigen of embryonal carcinoma cells to\( + ^{t^{12} } \) at the murineT/t complex have been extended and confirm that only the lethal haplotype t12- and none of the other five lethal haplotypes-affects the quantitative expression of F9 antigen on sperm. Cytotoxicity tests on preimplantation embryos show that t12 homozygotes are less susceptible to antiF9 serum than tw5 homozygotes, and that using specific antimutant haplotype antisera prepared against sperm, t12 antigen is detectable on morulae, whereas tw5 antigen is not.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Artzt, K. and Bennett, D.: Serological analysis of sperm of antigenically crossreactingT/t haplotypes and their recombinants.Immunogenetics 5:97–107, 1977
Artzt, K., Bennett, D., and Jacob, F.: Primitive teratocarcinoma cells express a differentiation antigen specified by a gene at the T locus in the mouse.Proc. Natl. Acad. Sci. U.S.A. 71:811–814, 1974
Artzt, K., Dubois, P., Bennett, D., Condamine, H., Babinet, C., and Jacob, F.: Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture.Proc. Natl. Acad. Sci. U.S.A. 70:2988–2992, 1973
Artzt, K., Hamburger, L., Jakob, H., and Jacob, F.: Embryonic surface antigens: A ‘quasi-endodermal’ teratoma antigen.Dev. Biol. 51:152–157, 1976
Bennett, D.: The T-locus of the mouse.Cell 6:441–454, 1975
Dewey, M.J., Gearhart, J.D., and Mintz, B.: Cell surface antigens of totipotent mouse teratocarcinoma cells grownin vivo: their relation to embryo, adult, and tumor antigens.Dev. Biol. 55:359–374, 1977
Edidin, M., Patthey, H.L., McGuire, E.J., and Sheffield, W.D.: An antiserum to ‘embryoid body’ tumor cells that reacts with normal embryos.In N.G. Anderson and J.H. Coggin, Jr. (eds.):Embryonic and Fetal Antigens in Cancer; pp. 239–248, Natl. Tech. Info. Serv. U.S. Dept. of Commerce, Springfield, Virginia, 1971
Gooding, L.R. and Edidin, M.: Cell surface antigens of a mouse testicular teratoma. Identification of an antigen physically associated with H-2 antigens on tumour cells.J. Exp. Med. 140:61–78, 1974
Jacob, F.: Mouse teratocarcinoma and embryonic antigens.Immunol. Rev. 33:3–32, 1977
Kemler, R., Babinet, C., Condamine, H., Gachelin, G., Guenet, J.L., and Jacob, F.: Embryonal carcinoma antigen and the T/t locus of the mouse.Proc. Natl. Acad. Sci. U.S.A. 73:4080–4084, 1976
Klein, J. and Hammerberg, C.: The control of differentiation by the T-complex.Immunol. Rev. 33:70–104, 1976
Lyon, M.F. and Bechtol, K.B.: Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion.Genet. Res. 30:62–76, 1977
Stern, P.L., Martin, G.R., and Evans, M.J.: Cell surface antigens of clonal teratocarcinoma cells at various stages of differentiation.Cell 6:455–465, 1975
Webb, C.G., Gall, E., and Edelman, G.M.: Synthesis and distribution of H-2 antigens in preimplantation mouse embryos.J. Exp. Med. 146:923–932, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marticorena, P., Artzt, K. & Bennett, D. Relationship of F9 antigen and genes of theT/t complex. Immunogenetics 7, 337–347 (1978). https://doi.org/10.1007/BF01844023
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01844023