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The firstH- 2 mutant workshop

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Conclusion

The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 availableH- 2 variants aretrue mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of theH- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected byH- 2 mutations and thus, apparently, are controlled by a single gene.

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Authors and Affiliations

  1. Department of Radiation Therapy, Harvard Medical School and Shields Warren Radiation Laboratory, New England Deaconess Hospital, 02115, Boston, Massachusetts

    Henry I. Kohn & Roger W. Melvold

  2. Abteilung Immungenetik, Max-Planck-Institut für Biologie, Corrensstrasse 42, 7400, Tübingen 1, Federal Republic of Germany

    Jan Klein

  3. Departments of Microbiology, Immunology, and Cell Biology, Albert Einstein College of Medicine, 10461, Bronx, New York

    Stanley G. Nathenson

  4. Department of Pediatrics, RD20, University of Washington School of Medicine, 98195, Seattle, Washington

    Donald Pious

  5. Department of Genetics, Washington University School of Medicine, 63110, St. Louis, Missouri

    Donald C. Shreffler

Authors
  1. Henry I. Kohn
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  2. Jan Klein
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  3. Roger W. Melvold
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  4. Stanley G. Nathenson
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  5. Donald Pious
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  6. Donald C. Shreffler
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May 17–19, 1978, Woods Hole, Massachusetts. Sponsored by the U.S. National Institute of Allergy and Infectious Diseases and the National Cancer Institute.

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Kohn, H.I., Klein, J., Melvold, R.W. et al. The firstH- 2 mutant workshop. Immunogenetics 7, 279–294 (1978). https://doi.org/10.1007/BF01844019

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