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Multi-Locus control of MLC reactions in rhesus monkeys

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Abstract

The genetic basis for MLC reactivity in rhesus monkeys was further investigated. Cells from anintra-RhLA recombinant monkey were MLC reactive with those of an SD-identical sib and with each of two sets of homozygous typing cells carrying either paternal haplotype. Also, cells from a pair ofRhLA- identical sibs reacted in MLC with each other, as well as with three genotypically different siblings. This excludes control of MLC reactivity by the conventionalD locus only. Thus the results selected for presentation provide formal evidence for the existence of at least one additional MLC locus, namedD′. The possibility thatD′ exerts its influence on MLC reactivity only after alloimmunization is discussed.

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Authors and Affiliations

  1. The Primate Center TNO, Rijswijk, The Netherlands

    Michael B. Widmer & Hans Balner (member of the Biology-Medical Research Division of the European Communities)

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  1. Michael B. Widmer
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  2. Hans Balner
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Widmer, M.B., Balner, H. Multi-Locus control of MLC reactions in rhesus monkeys. Immunogenetics 7, 155–164 (1978). https://doi.org/10.1007/BF01844001

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