Abstract
Evidence is presented for a crossover between the genes coding for the serologically determined (SD) antigens on erythrocytes and an immune response gene (Ir-GAT) controlling immune response to the synthetic polypeptide GAT within theB complex, the MHC of chickens. TheIr-GAT 1 andIr-GAT 19 alleles control low and high immune response to GAT, respectively. Both low and high responders were recovered as recombinants fromB 1 B 1 andB 19 B 19 birds. The low-responder haplotypes are homozygous for theIr-GAT 1 allele and the high-responder haplotypes carry theIr-GAT 19 allele. Mortality forB 1 B 1 nonresponder birds was 39%, compared with 19% for theB 1 B 1 high responders; this suggests the possibility that genes located within the immune response region of theB complex exert some genetic control over viability and survival.
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Abbreviations
- MHC:
-
major histocompatibility complex
- Ir:
-
immune response
- SD:
-
serologically determined
- GA:
-
(L-glutamic acid60, L-alanine40) n
- DNP-GL:
-
dinitrophenyl-(L-glutamic acid60, L-lysine40)
- PLL:
-
poly-L-lysine
- (T,G)-A--L:
-
poly-(L-tyrosine-L-glutamic acid)-poly-D, L-alanine-poly-L-lysine
- GAT, GAT10 :
-
(L-glutamic acid60 L-alanine30 L-tyrosine10) n
- CFA:
-
complete Freund's adjuvant
- PBS:
-
phosphate-buffered saline
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Pevzner, I.Y., Trowbridge, C.L. & Nordskog, A.W. Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system. Immunogenetics 7, 25–33 (1978). https://doi.org/10.1007/BF01843984
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DOI: https://doi.org/10.1007/BF01843984