Veterinary Research Communications

, Volume 18, Issue 5, pp 397–415 | Cite as

Reflections on the pathogenesis of diseases caused by the acute avian leukosis/sarcoma viruses with special reference to avian erythroblastosis

  • C. Darcel
Virology Review Article
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Abstract

The various diseases that follow experimental infection with the acute and non-acute avian oncoviruses are discussed with special reference to the pathogenesis of avian erythroblastosis. One view, based onin vitro studies, sees erythroblastosis as the product of a failure in the differentiation of virus-infected stem cells to mature erythrocytes, as a result of cell ‘transformation’. The results of somein vivo studies, however, point to a resemblance of the disease to a haemolytic anaemia, where cellular death is an important component. It seems probable that the disease is the result of transformation of cells of the erythroblastic series followed by the death of many of these cells due to influences that have not yet been determined. Determination of the causes of this cellular death may prove to be as important for our understanding of the problem of leukaemia as the work that has already been accomplished in explaining the causes of cell transformation. It is also suggested that the tendency ofgs amino acid sequences of the avian leukosis viruses and mouse leukaemia viruses to form fusion proteins with a variety of proto-oncogenes may be part of a wider phenomenon, and that these sequences may fuse with other proteins, altering their properties. More work is required on the possibility that there is an undiscovered immunological component in the progression of the L/S diseases.

Keywords

apoptosis avian chicken erythroblastosis leukosis oncogene virus 

Abbreviations

AGID

agar gel immunodiffusion

AEV

avian erythroblastosis virus

AMV

avian myeloblastosis virus

ATPase

adenosine triphosphatase

CEF

chicken embryo fibroblasts

EGF

epidermal growth factor

ELISA

enzyme-linked immunosorbent assay

gs

group specific antigen

gag

viral gene expressing the group specific antigen

L/S

leukosis/sarcoma

LLV

lymphoid leukosis virus

PEBLEs

proerythroblast-like elements

REV

reticuloendotheliosis virus

RAV-1 etc.

Rousassociated virus isolates

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Copyright information

© Kluwer Academic Publishers bv 1994

Authors and Affiliations

  • C. Darcel
    • 1
  1. 1.Palliser Animal Health Laboratories LtdLethbridgeCanada

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