Abstract
The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12±0.01 h and 1.94±0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2±0.01 L/kg and 92.9±3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.
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Abbreviations
- SEM:
-
standard error of the mean
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Rampal, S., Srivastava, A.K. & Chaudhary, R.K. Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration. Vet Res Commun 17, 219–225 (1993). https://doi.org/10.1007/BF01839170
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DOI: https://doi.org/10.1007/BF01839170