Inflammation Research

, Volume 44, Issue 11, pp 499–503 | Cite as

Cardiac release of histamine after ventricular fibrillation and defibrillation during insertion of implantable cardioverter defibrillators (ICD)

  • G. Valen
  • M. Runsiö
  • A. Öwall
  • J. Kaszaki
  • S. Nagy
  • M. Rosenqvist
  • L. Bergfeldt
  • J. Vaage


Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5min after DEF (18–24 Joules). Basal arterial histamine was 2.5±6nmol/1, and did not increase after VF. The histamine level in CS was 1.1±0.2nmol/1 before VF (p < 0.008 compared to arterial), and increased to 2.5 ± 0.6 nmol/1 immediately after (p < 0.045 compared to basal), to 3 ± 1.1 nmol/1 2 min after (p < 0.45), and to 2.4 ± 0.8 nmol/1 5min after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in coronary venous blood, suggesting cardiac release of histamine.

Key words

Histamine Hypoperfusion Implantable defibrillators Ventricular fibrillation 


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Copyright information

© Birkhäuser Verlag, Basel 1995

Authors and Affiliations

  • G. Valen
    • 1
  • M. Runsiö
    • 3
  • A. Öwall
    • 4
  • J. Kaszaki
    • 4
  • S. Nagy
    • 2
  • M. Rosenqvist
    • 2
  • L. Bergfeldt
    • 2
  • J. Vaage
    • 1
  1. 1.Departments of Thoracic SurgeryKarolinska HospitalStockholmSweden
  2. 2.CardiologyKarolinska HospitalStockholmSweden
  3. 3.Cardiothoracic Anaesthetics and Intensive CareKarolinska HospitalStockholmSweden
  4. 4.Institute of Experimental SurgerySzent-Györgyi Albert Medical UniversitySzegedHungary

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