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pS2 expression in primary breast carcinomas: Relationship to clinical and histological features and survival

Breast Cancer Research and Treatment volume 21, pages 111–119 (1992)Cite this article

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Summary

pS2 protein expression has been reported to have prognostic significance in human breast carcinomas and to correlate with estrogen receptor positivity, although these findings have not been confirmed by all investigators. pS2 positivity was compared to various clinical and histologic parameters in a retrospective study of 290 patients (median follow-up 7.2 years) and significantly correlated with tumor grade and estrogen receptor content (p=0.001 and p=0.0007, respectively). Significant associations between pS2 positivity and lymph node metastases, T stage, histologic tumor type, and patient age were not observed. Univariate and multivariate analyses (controlling for estrogen receptor content, T and N stage) of the patient population at large showed that pS2 positivity was not predictive of disease-free or overall survival. Univariate analysis of lymph node negative patients demonstrated that both pS2 and estrogen receptor positivity were significantly associated with a better outcome. Multivariate analysis of these patients, however, showed that only estrogen receptor data had independent prognostic significance. This study suggests that immunohistochemical analysis for pS2 protein expression will not contribute additional prognostic information if the estrogen receptor content is known.

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Affiliations

  1. Department of Surgery, Massachusetts General Hospital, 02114, Boston, MA, USA

    William C. Wood

  2. Department of Orthopaedic Biomechanics Laboratory, Massachusetts General Hospital, 02114, Boston, MA, USA

    Michael A. Stracher

  3. Department of Radiation Therapy, Massachusetts General Hospital, 02114, Boston, MA, USA

    Laurent H. Schwartz

  4. Department of Pathology, Cox 5, Massachusetts General Hospital, Fruit Street, 02114, Boston, MA, USA

    Ann D. Thor, Frederick C. Koerner & Susan M. Edgerton

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  1. Ann D. Thor
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  2. Frederick C. Koerner
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  3. Susan M. Edgerton
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  4. William C. Wood
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  5. Michael A. Stracher
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  6. Laurent H. Schwartz
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Thor, A.D., Koerner, F.C., Edgerton, S.M. et al. pS2 expression in primary breast carcinomas: Relationship to clinical and histological features and survival. Breast Cancer Res Tr 21, 111–119 (1992). https://doi.org/10.1007/BF01836957

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  • DOI: https://doi.org/10.1007/BF01836957

Key words

  • breast cancer
  • estrogen receptor
  • prognosis
  • prognostic factors
  • pS2