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Breast Cancer Research and Treatment

, Volume 21, Issue 2, pp 95–100 | Cite as

Human papillomavirus in breast cancer

  • Anna Di Lonardo
  • Aldo Venuti
  • Maria Luisa Marcante
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Summary

Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and thein situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences byin situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.

Key words

breast cancer HPV in situ hybridization PCR 

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Anna Di Lonardo
    • 1
  • Aldo Venuti
    • 1
  • Maria Luisa Marcante
    • 1
  1. 1.Lab. of VirologyCRS, Regina Elena Institute for Cancer ResearchRomeItaly

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