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Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor

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Abstract

A case of acute monocytic leukemia with rearrangement of the immunoglobulin heavy-chain gene and strong cytoplasmic immunoglobulin expression in a young patient treated with multi-drug chemotherapy for primary seminomatous germ cell tumor 13 months earlier is reported. The short latency period from the beginning of therapy for primary germ cell tumor and the abrupt onset of leukemia with no identifiable prodrome bear similarities to podophyllotoxin-related leukemias.

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Authors and Affiliations

  1. Department of Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    H. T. Greinix

  2. Institute of Pathology, University of Graz, Austria

    C. Beham-Schmid & G. Hoefler

  3. Division of Hematology, Department of Internal Medicine, University of Graz, Austria

    H. Silly & H. L. Seewann

  4. Division of Oncology, Department of Internal Medicine, University of Graz, Austria

    A. Kasparek

Authors
  1. H. T. Greinix
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  2. C. Beham-Schmid
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  3. H. Silly
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  4. G. Hoefler
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  5. A. Kasparek
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  6. H. L. Seewann
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Supported by a grant from theFonds zur Förderung der wissen-schaftlichen Forschung (P09044-MED)

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Greinix, H.T., Beham-Schmid, C., Silly, H. et al. Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor. Ann Hematol 70, 109–112 (1995). https://doi.org/10.1007/BF01834391

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  • DOI: https://doi.org/10.1007/BF01834391

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