Abstract
Tumorous-manifestation of hairy cell leukemia in a patient treated with IFNα for 7 years is described. After this time, while the patient still was in hematological remission, a tumorous involvement of the lung by hairy cells developed and was successfully treated by surgery. No differences in the phenotype of hairy cells in the lung tumor, in the bone marrow, or in the blood could be detected.
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References
Anderson KC, Boyd AW, Fischer DC, Leslie D, Schlossmann SF, Nadler LM (1985) Hairy cell leukemia: a tumor of preplasma cells. Blood 65:620–629
Aronowitz J, Baral E, Dalcal BI (1993) Late transition of hairy cell leukemia to multiple myeloma. Am J Hematol 44:216–217
Jaiyesimi IA, Kantarjian HM, Estey EH (1993) Advances in therapy for hairy cell leukemia. Cancer 72:5–16
Kampmeier P, Spielberger R, Dickstein J, Mick R, Golomb H (1994) Increased incidence of second neoplasms in patients treated with interferonα 2b for hairy cell leukemia: a clinicopathologic assessment. Blood 83:2931–2938
Mercieca J, Matutes E, Moskovic E, MacLennan K, Matthey F, Costello C, Behrens J, Basu S, Roath S, Fairhead S, Flandrin G, Brizard A, Catovsky D (1992) Massive abdominal lymphadenopathy in hairy cell leukaemia: a report of 12 cases. Br J Haematol 82:547–554
Robbins BA, Ellison DJ, Spinosa JC, Carey CA, Lukes RJ, Poppema S, Saven A, Piro LD (1993) Diagnostic application of two-color flow cytometry in 161 cases of hairy cell leukemia. Blood 82:1277–1287
Smalley RV, Connors J, Tuttle RL, Anderson S, Robinson W, Whisnant JK (1992) Splenectomy vs. alpha interferon: a randomized study in patients with previously untreated hairy cell leukemia. Am J Hematol 41:13–18
Smith JW, Longo DL, Urba WJ, Clark JW, Watson T, Beveridge J, Conlon KC, Sznol M, Creekmore SP, Alvord WG, Lawrence JB, Steis RG (1991) Prolonged, continuous treatment of hairy cell leukemia patients with recombinant interferonα2a. Blood 78:1664–1671
Vedantham S, Gamliel H, Golomb HM (1992) Mechanism of interferon action in hairy cell leukemia: a model of effective cancer biotherapy. Cancer Res 52:1056–1066
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Huhn, D., Oertel, J., Serke, S. et al. Tumorous manifestation of hairy cell leukemia after long-term treatment with interferon alpha. Ann Hematol 70, 103–105 (1995). https://doi.org/10.1007/BF01834389
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DOI: https://doi.org/10.1007/BF01834389