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Journal of Mathematical Biology

, Volume 14, Issue 2, pp 195–201 | Cite as

A combinatorial problem in pharmacology

  • George H. Weiss
  • John Rice
Article

Abstract

A novel coding scheme is used to enumerate configurations in a combinatorial problem arising in research on effects of drugs or radiation on DNA.

Key words

DNA damage DNA crosslinks Chemotherapy 

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References

  1. 1.
    Kohn, K. W., Erickson, L. C., Ewig, R. A. G., Friedman, C. A.: Fractionation of DNA from mammalian cells by alkaline elution. Biochem.15, 4629–4637 (1976)CrossRefGoogle Scholar
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    Ewig, R. A. G., Kohn, K. W.: DNA-protein crosslinking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells. Cancer Res.38, 3197–3203 (1978)Google Scholar
  3. 3.
    Kohn, K. W.: DNA as a target in cancer chemotherapy measurement of macromolecular DNA damages produced in mammalian cells by anticancer agents and carcinogens. In: Methods in cancer research, Busch, H., DeVita, V. (eds.), Vol. 16, pp. 291–345. New York: Academic Press 1979Google Scholar
  4. 4.
    Cox, D. R.: Renewal theory, p. 66. New York: John Wiley & Sons 1962Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • George H. Weiss
    • 1
  • John Rice
    • 2
  1. 1.Division of Computer Research and TechnologyNational Institutes of HealthBethesdaUSA
  2. 2.University of California at San DiegoLa JollaUSA

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