Journal of Mathematical Biology

, Volume 14, Issue 2, pp 195–201 | Cite as

A combinatorial problem in pharmacology

  • George H. Weiss
  • John Rice


A novel coding scheme is used to enumerate configurations in a combinatorial problem arising in research on effects of drugs or radiation on DNA.

Key words

DNA damage DNA crosslinks Chemotherapy 


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    Kohn, K. W.: DNA as a target in cancer chemotherapy measurement of macromolecular DNA damages produced in mammalian cells by anticancer agents and carcinogens. In: Methods in cancer research, Busch, H., DeVita, V. (eds.), Vol. 16, pp. 291–345. New York: Academic Press 1979Google Scholar
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    Cox, D. R.: Renewal theory, p. 66. New York: John Wiley & Sons 1962Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • George H. Weiss
    • 1
  • John Rice
    • 2
  1. 1.Division of Computer Research and TechnologyNational Institutes of HealthBethesdaUSA
  2. 2.University of California at San DiegoLa JollaUSA

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