Cancer Causes & Control

, Volume 5, Issue 1, pp 53–60 | Cite as

The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States)

  • Joanne F. Dorgan
  • Marsha E. Reichman
  • Joseph T. Judd
  • Charles Brown
  • Christopher Longcope
  • Arthur Schatzkin
  • William S. Campbell
  • Charlene Franz
  • Lisa Kahle
  • Philip R. Taylor
Research Papers

Abstract

We undertook a cross-sectional study in 107 premenopausal women in Maryland (United States) of alcohol intake and hormonal status in order to evaluate whether plasma hormone levels might mediate the reported positive relation between alcohol ingestion and breast cancer risk. Alcohol ingestion was estimated using a drinking pattern questionnaire, a food frequency questionnaire, and seven-day food records. Fasting blood specimens were collected on days 5–7, 12–15, and 21–23 of each participant's menstrual cycle and pooled to create follicular, midcycle, and luteal phase samples, respectively, for analysis. Estrone, estrone sulfate, estradiol, androstenedione, and dehydropiandrosterone sulfate (DHEAS) in plasma were measured by radioimmunoassay, and sex-hormone binding globulin (SHBG) was measured by an immunoradiometric assay. After adjusting for age, weight, and total energy intake, alcohol ingestion was not associated with plasma estrogens in the follicular, midcycle, or luteal phases of the menstrual cycle, nor with the level of SHBG or DHEAS in plasma averaged from the three phases of the cycle. Alcohol, however, was significantly positively associated with the average level of plasma androstenedione. Based on these cross-sectional findings among premenopausal women, the increased risk of breast cancer related to alcohol ingestion does not appear to be mediated by elevated plasma estrogen levels. Androstenedione, however, may mediate the alcohol/breast cancer-association.

Key words

Alcohol androgens estrogens ethyl alcohol United States 

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References

  1. 1.
    Rosenberg L, Slone D, Shapiro S, et al. Breast cancer and alcoholic-beverage consumption.Lancet 1982;i: 267–71.Google Scholar
  2. 2.
    Schatzkin A, Jones DY, Hoover RN, et al. Alcohol consumption and breast cancer in the epidemiologic follow-up study of the First National Health and Nutrition Examination Survey.N Engl J Med 1987;316: 1169–73.PubMedGoogle Scholar
  3. 3.
    Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Hennekens CH, Speizer FE. Moderate alcohol consumption and the risk of breast cancer.N Engl J Med 1987;316: 1174–80.PubMedGoogle Scholar
  4. 4.
    Kato I, Tominaga S, Terao C. Alcohol consumption and cancers of hormone related organs in females.Jpn J Clin Oncol 1989;19: 202–7.PubMedGoogle Scholar
  5. 5.
    La Vecchia C, Negri E, Parazzini F, et al. Alcohol and breast cancer: update from an Italian case-control study.Eur J Cancer Clin Oncol 1989;25: 1711–7.PubMedGoogle Scholar
  6. 6.
    Richardson S, de Vincenzi I, Pujol H, Gerber M. Alcohol consumption in a case-control study of breast cancer in Southern France.Int J Cancer 1989;44: 84–9.PubMedGoogle Scholar
  7. 7.
    Adami HO, Lund E, Bergstrom R, Meirik O. Cigarette smoking, alcohol consumption and risk of breast cancer in young women.Br J Cancer 1988;58: 832–7.PubMedGoogle Scholar
  8. 8.
    Harris RE, Spritz N, Wynder EL. Studies of breast cancer and alcohol consumption.Prev Med 1988;17: 676–82.PubMedGoogle Scholar
  9. 9.
    Van't Veer P, Kok FJ, Hermus RJJ, Sturmans F. Alcohol dose, frequency and age at first exposure in relation to the risk of breast cancer.Int J Epidemiol 1989;18: 511–7.PubMedGoogle Scholar
  10. 10.
    Ewertz M. Alcohol consumption and breast cancer risk in Denmark.Cancer Causes Control 1991;2: 247–52.PubMedGoogle Scholar
  11. 11.
    Friedenreich CM, Howe GR, Miller AB, Jain MG. A cohort study of alcohol consumption and risk of breast cancer.Am J Epidemiol 1993;137: 512–20.PubMedGoogle Scholar
  12. 12.
    Rohan TE, McMichael AJ. Alcohol consumption and risk of breast cancer.Int J Cancer 1988;41: 695–9.PubMedGoogle Scholar
  13. 13.
    Harvey EB, Schairer C, Brinton LA, Hoover RN, Fraumeni JF Jr. Alcohol consumption and breast cancer.JNCI 1987;78: 657–61.PubMedGoogle Scholar
  14. 14.
    Young TB. A case-control study of breast cancer and alcohol consumption habits.Cancer 1989;64: 552–8.PubMedGoogle Scholar
  15. 15.
    Moore JW, Clark GMG, Bulbrook RD, et al. Serum concentrations of total and non-protein bound oestradiol in patients with breast cancer and in normal controls.Int J Cancer 1982;29: 17–21.PubMedGoogle Scholar
  16. 16.
    Bruning PF, Bonfrer JMG, Hart AAM. Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk.Br J Cancer 1985;51: 479–84.PubMedGoogle Scholar
  17. 17.
    Meyer F, Brown JB, Morrison AS, MacMahon B. Endogenous sex hormones, prolactin, and breast cancer in premenopausal women.JNCI 1986;77: 613–6.PubMedGoogle Scholar
  18. 18.
    Bernstein L, Yuan J, Ross RK, et al. Serum hormone levels in pre-menopausal Chinese women in Shanghai and white women in Los Angeles: Results from two breast cancer case-control studies.Cancer Causes Control 1990;1: 51–8.PubMedGoogle Scholar
  19. 19.
    Secreto G, Recchione C, Cavalleri A, Miraglia M, Dati V. Circulating levels of testosterone, 17-β estradiol, luteinizing hormone and prolactin in postmenopausal breast cancer patients.Br J Cancer 1983;47: 269–75.PubMedGoogle Scholar
  20. 20.
    Secreto G, Recchione C, Fariselli G, Di Pietro S. High testosterone and low progesterone circulating levels in premenopausal patients with hyperplasia and cancer of the breast.Cancer Res 1984;44: 841–4.PubMedGoogle Scholar
  21. 21.
    Secreto G, Toniolo P, Berrino F, et al. Increased androgenic activity and breast cancer risk in premenopausal women.Cancer Res 1984;44: 5902–5.PubMedGoogle Scholar
  22. 22.
    Hill P, Garbaczewski L, Kasumi F. Plasma testosterone and breast cancer (Letter).Eur J Cancer Clin Oncol 1985;21: 1265–6.PubMedGoogle Scholar
  23. 23.
    Secreto G, Toniolo P, Pisani P, et al. Androgens and breast cancer in premenopausal women.Cancer Res 1989;49: 471–6.PubMedGoogle Scholar
  24. 24.
    Secreto G, Toniolo P, Berrino F, et al. Serum and urinary androgens and risk of breast cancer in postmenopausal women.Cancer Res 1991;51: 2572–6.PubMedGoogle Scholar
  25. 25.
    Gordon GB, Bush TL, Helzlsouer KJ, Miller SR, Comstock GW. Relationship of serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing postmenopausal breast cancer.Cancer Res 1990;50: 3859–62.PubMedGoogle Scholar
  26. 26.
    O'Malley BW, Strott CA. Steroid hormones: metabolism and mechanism of action. In: Yen SC, Jaffe RB, eds.Reproductive Endocrinology, 3rd ed. Philadelphia: WB Saunders, 1991; 159.Google Scholar
  27. 27.
    Ota DM, Jones LA, Jackson GL, Jackson PM, Kemp K, Bauman D. Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients.Cancer 1986;57: 558–62.PubMedGoogle Scholar
  28. 28.
    Jones LA, Ota DM, Jackson GA, et al. Bioavailability of estradiol as a marker for breast cancer risk assessment.Cancer Res 1987;47: 5224–9.PubMedGoogle Scholar
  29. 29.
    Takatani O, Kosano H, Okumoto T, Akamatsu K, Tamakuma S, Hiraide H. Distribution of estradiol and percentage of free testosterone in sera of Japanese women: Preoperative breast cancer patients and normal controls.JNCI 1987;79: 1199–204.PubMedGoogle Scholar
  30. 30.
    Takatani O, Okumoto T, Kosano H, Nishida M, Hiraide H, Tamakuma S. Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women.Cancer Res 1989;49: 3109–12.PubMedGoogle Scholar
  31. 31.
    Reed MJ, Cheng RW, Noel CT, Dudley HAF, James VHT. Plasma levels of estrone, estrone sulfate, and estradiol and the percentage of unbound estradiol in postmenopausal women with and without breast disease.Cancer Res 1983;43: 3940–3.Google Scholar
  32. 32.
    Moore JW, Clark GMG, Hoare SA, et al. Binding of oestradiol to blood proteins and aetiology of breast cancer.Int J Cancer 1986;38: 625–30.PubMedGoogle Scholar
  33. 33.
    Bennett IC, McCaffrey JF, McCaffrey E, Wyatt B. Serum oestradiol in women with and without breast disease.Br J Cancer 1990;61: 142–6.PubMedGoogle Scholar
  34. 34.
    Langley MS, Hammond GL, Bardsley A, Sellwood RA, Anderson DC. Serum steroid binding proteins and the bioavailability of estradiol in relation to breast diseases.JNCI 1985;75: 823–9.PubMedGoogle Scholar
  35. 35.
    James VHT, Green JRB, Walker JG, et al. The endocrine status of postmenopausal cirrhotic women. In: Langer M, Chiandussi L, Chopra IJ, Martini L, eds.The Endocrines and the Liver. New York: Academic Press, 1982: 417–9.Google Scholar
  36. 36.
    Jasonni VM, Bulletti C, Bolelli GF, et al. Estrone sulfate, estrone and estradiol concentrations in normal and cirrhotic postmenopausal women.Steroids 1983;41: 569–73.PubMedGoogle Scholar
  37. 37.
    Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG. The epidemiology of serum sex hormones in postmenopausal women.Am J Epidemiol 1989;129: 1120–31.PubMedGoogle Scholar
  38. 38.
    Gavaler JS, Love K, Van Thiel D, et al. An international study of the relationship between alcohol consumption and postmenopausal estradiol levels.Alcohol Alcohol Suppl 1991;1: 327–30.PubMedGoogle Scholar
  39. 39.
    Gavaler JS, Van Thiel DH. The association between moderate alcoholic beverage consumption and serum estradiol and testosterone levels in normal postmenopausal women: Relationship to the literature.Alcohol Clin Exp Res 1992;16: 87–92.PubMedGoogle Scholar
  40. 40.
    Katsouyanni K, Boyle P, Trichopoulos D. Diet and urine estrogens among postmenopausal women.Oncology 1991;48: 490–4.PubMedGoogle Scholar
  41. 41.
    London S, Willett W, Longcope C, McKinlay S. Alcohol and other dietary factors in relation to serum hormone concentrations in women at climacteric.Am J Clin Nutr 1991;53: 166–71.PubMedGoogle Scholar
  42. 42.
    Wilsnack SC, Klassen AD, Wilsnack RW. Drinking and reproductive dysfunction among women in a 1981 national survey.Alcohol Clin Exp Res 1984;8: 451–8.PubMedGoogle Scholar
  43. 43.
    Valimaki M, Pelkonen R, Salaspuro M, Harkonen M, Hirvonen E, Ylikahri R. Sex hormones in amenorrheic women with alcoholic liver disease.J Clin Endocrinol Metab 1984;59: 133–8.PubMedGoogle Scholar
  44. 44.
    Valimaki M, Harkonen M, Ylikahri R. Acute effects of alcohol on female sex hormones.Alcohol Clin Exp Res 1983;7: 289–93.PubMedGoogle Scholar
  45. 45.
    Mendelson JH, Lukas SE, Mello NK, Amass L, Ellingboe J, Skupny A. Acute alcohol effects on plasma estradiol levels in women.Psychopharmacology 1988;94: 464–7.PubMedGoogle Scholar
  46. 46.
    Carlstrom K, Eriksson S, Rannevik G. Sex steroids and steroid binding proteins in female alcoholic liver disease.Acta Endocrinol 1986;111: 75–9.PubMedGoogle Scholar
  47. 47.
    Reichman ME, Judd JT, Longcope C, et al. Effects of moderate alcohol consumption on plasma and urinary hormone concentrations in premenopausal women.JNCI 1993;85: 722–7.PubMedGoogle Scholar
  48. 48.
    Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L. A data-based approach to diet questionnaire design and testing.Am J Epidemiol 1986;124: 453–69.PubMedGoogle Scholar
  49. 49.
    Schakel SF, Sievert YA, Buzzard IM. Sources of data for developing and maintaining a nutrient database.J Am Diet Assoc 1988;88: 1268–71.PubMedGoogle Scholar
  50. 50.
    US Department of Agriculture. Composition of Foods: Beverages; Raw, Processed, Prepared. US Department of Agriculture,Agriculture Handbook No. 8-14, 1986.Google Scholar
  51. 51.
    Longcope C, Franz C, Morello C, Baker R, Johnston CC. Steroid and gonadotropin levels in women during the peri-menopausal years.Maturitas 1986;8: 189–96.PubMedGoogle Scholar
  52. 52.
    Longcope C, Hui SL, Johnston CC. Free estradiol, free testosterone and sex hormone binding globulin in perimenopausal women.J Clin Endocrinol Metab 1987;64: 513–8.PubMedGoogle Scholar
  53. 53.
    Malin H, Wilson RW, Williams GD. 1983 NHIS Alcohol/Health Practices Supplement: Preliminary findings. In:Proceedings of the 1985 Public Health Conference on Records and Statistics. Hyattsville, MD: US Dept. of Health and Human Services, 1985; DHHS Pub. No. (PHS) 86–1214.Google Scholar
  54. 54.
    Willett W.Nutritional Epidemiology. New York: Oxford University Press, 1990: 245–71.Google Scholar
  55. 55.
    SAS Institute, Inc.SAS User's Guide, Version 5. Cary, NC: SAS Institute Inc., 1985.Google Scholar
  56. 56.
    Abraham GE. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle.J Clin Endocrinol Metab 1974;39: 340–6.PubMedGoogle Scholar
  57. 57.
    Cobb CF, Van Thiel DH. Mechanism of ethanol-induced adrenal stimulation.Alcohol Clin Exp Res 1982;6: 202–6.PubMedGoogle Scholar
  58. 58.
    Mello NK, Mendelson JH, Teoh SK. Neuroendocrine consequences of alcohol abuse in women.Ann NY Acad Sci 1989;562: 211–40.PubMedGoogle Scholar
  59. 59.
    Deslypere JP, Verdonck L, Vermeulen A. Fat tissue: A steroid reservoir and site of steroid metabolism.J Clin Endocrinol Metab 1985;61: 564–70.PubMedGoogle Scholar
  60. 60.
    Goldin BR, Gorbach SL. Effect of diet on the plasma levels, metabolism, and excretion of estrogens.Am J Clin Nutr 1988;48: 787–90.PubMedGoogle Scholar
  61. 61.
    Chambers GK. The genetics of human alcohol metabolism.Gen Pharmac 1990;21: 267–72.Google Scholar
  62. 62.
    Mendelson JH, Mello NK. Chronic alcohol effects on anterior pituitary and ovarian hormones in healthy women.J Pharmacol Exp Ther 1988;245: 407–12.PubMedGoogle Scholar
  63. 63.
    Henderson BE, Ross R, Bernstein L. Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation Award lecture.Cancer Res 1988;48: 246–53.PubMedGoogle Scholar
  64. 64.
    Ernster VL, Wrensch MR, Petrakis NL, et al. Benign and malignant breast disease: Initial study results of serum and breast fluid analyses of endogenous estrogens.JNCI 1987;79: 749–60.Google Scholar
  65. 65.
    Moore JW, Thomas BS, Wang DY. Endocrine status and the epidemiology and clinical course of breast cancer.Cancer Surveys 1986;5: 537–59.PubMedGoogle Scholar
  66. 66.
    Miller WR. Pathways of hormone metabolism in normal and non-neoplastic breast tissue.Ann NY Acad Sci 1990;586: 53–9.PubMedGoogle Scholar
  67. 67.
    Lieber CS, Baraona E, Leo MA, Garro A. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition.Mutat Res 1987;186: 201–33.PubMedGoogle Scholar

Copyright information

© Rapid Communications of Oxford Ltd 1994

Authors and Affiliations

  • Joanne F. Dorgan
    • 1
  • Marsha E. Reichman
    • 2
  • Joseph T. Judd
    • 3
  • Charles Brown
    • 1
  • Christopher Longcope
    • 4
  • Arthur Schatzkin
    • 1
  • William S. Campbell
    • 1
  • Charlene Franz
    • 4
  • Lisa Kahle
    • 5
  • Philip R. Taylor
    • 1
  1. 1.Division of Cancer Prevention and ControlNational Cancer InstituteBethesdaUSA
  2. 2.BethesdaUSA
  3. 3.Beltsville Human Nutrition Research Center, ARSUSDABeltsvilleUSA
  4. 4.Department of Obstetrics and Gynecology and MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA
  5. 5.Information Management Services, Inc.Silver SpringUSA

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