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Effects of the cold pressor test on short-term fluctuations of finger arterial blood pressure and heart rate in normal subjects

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Abstract

The effect of the cold pressor test on autonomic cardiovascular control was studied non-invasively by means of spectrum analysis of periodic heart rate and blood pressure fluctuations in ten normal subjects. Fast Fourier Transform algorithm based on a 256-point time series (sampling rate 2 Hz, i.e. 2-min and 8-s) was used to estimate the amplitude spectra of heart rate and blood pressure rhythmicity at the low frequency (70–140 mHz) and respiration related frequency (230–270 mHz) band. Respiration rate was controlled at 250 mHz. Auto- and cross-spectral techniques were used to determine the complex relationship between systolic blood pressure and heart rate fluctuations in the frequency domain. The spectral pattern of systolic and diastolic blood pressure showed a marked increment of the absolute and relative (100 multiplied with absolute value/total area under the curve of the amplitude spectrum from 15–500 mHz) low frequency component: control vs. cold pressor test—systolic blood pressure—absolute values (in [mmHg/Hz1/2]): 634.4 ± 48.9 vs. 827.4 ± 69.9* relative values (in [%]): 26 ± 2 vs. 32 ± 2*; diastolic blood pressure —absolute values: 433.2 ± 42.3 vs. 537.2 ± 45.8* relative values: 35 ± 3 vs. 40 ± 2*, (average ± SEM, *P < 0.05). The cold pressor test induced no change in average heart rate; the absolute low frequency component in heart rate spectra increased clearly during the test: low frequency component (in [bpm/Hz1/2]): 586.9 ± 89.9 vs. 712.0 ± 91.4*, while the relative low frequency component did not change: 29 ± 3 vs. 30 ± 3. There was no alteration in the respiration related frequency component in all time series and in the transfer gain and phase functions during cold pressor test. We conclude that the cold pressor test increases low frequency systolic blood pressure fluctuations which reflects an increase in sympathetic vasomotor control. Furthermore the cold pressor test does not induce change in the transfer gain and phase characteristics of modulation of heart rate by systolic blood pressure.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine Necker, 156 rue de Vaugirard, 75015, Paris, France

    Frank Weise MD, Dominique Laude, Arlette Girard & Jean-Luc Elghozi MD, PhD

  2. Notocord Systems at Igny, France

    Philippe Zitoun MD

  3. Department of Internal Medicine at the University of Grenoble, Grenoble, France

    Jean-Philippe Siché MD

Authors
  1. Frank Weise MD
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  2. Dominique Laude
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  3. Arlette Girard
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  4. Philippe Zitoun MD
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  5. Jean-Philippe Siché MD
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  6. Jean-Luc Elghozi MD, PhD
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Weise, F., Laude, D., Girard, A. et al. Effects of the cold pressor test on short-term fluctuations of finger arterial blood pressure and heart rate in normal subjects. Clinical Autonomic Research 3, 303–310 (1993). https://doi.org/10.1007/BF01827331

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  • DOI: https://doi.org/10.1007/BF01827331

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