Clinical Autonomic Research

, Volume 2, Issue 2, pp 113–118 | Cite as

The circadian rhythm of atrial natriuretic peptide, vasoactive intestinal peptide, beta-endorphin and cortisol in healthy young and elderly subjects

  • P. Cugini
  • P. Lucia
  • L. Di Palma
  • M. Re
  • R. Canova
  • L. Gasbarrone
  • A. Cianetti
Research Paper

Abstract

Atrial natriuretic peptide, vasoactive intestinal peptide, beta-endorphin and cortisol are humoral variables characterized by a 24-h periodicity. We evaluated the circadian rhythm of these peptides and hormones in healthy subjects who were young (between 20–25 years) or elderly (between 65–75 years). All were on controlled diets. Blood samples were collected six times during a 24-h period (at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 h) beginning 8-h after start of recumbency. The time-related data were analysed by the Cosinor method in order to validate the circadian rhythm and to quantify rhythmometric parameters which included the midline estimate of rhythm (mesor). In contrast to the young subjects, Cosinor analysis failed to reveal a significant circadian rhythm in elderly subjects, for plasma cortisol. In elderly subjects oscillation (mesor) of atrial nutriuretic peptide was higher, while that of vasoactive intestinal peptide and beta—endorphins was lower. The results suggest changes in the physiological secretion of these three peptides in healthy elderly subjects.

Key words

Ageing ANP B-EP Circadian rhythm VIP 

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Copyright information

© Rapid Communications of Oxford Ltd. 1992

Authors and Affiliations

  • P. Cugini
    • 1
  • P. Lucia
    • 1
  • L. Di Palma
    • 1
  • M. Re
    • 1
  • R. Canova
    • 2
    • 3
  • L. Gasbarrone
    • 2
    • 3
  • A. Cianetti
    • 2
    • 3
  1. 1.II Clinica MedicaPoliclinico Umberto IItaly
  2. 2.Medical SemeioticsUniversity "La Sapienza"Italy
  3. 3.Department of Internal Medicine and Clinical Research LaboratoriesS. Camillo De Lellis HospitalRomeItaly

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