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The cooperation of cefotaxime and desacetyl-cefotaxime with respect to antibacterial activity and β-lactamase stability

Kooperation von Cefotaxim und Desacetyl-Cefotaxim in bezug auf antibakterielle Aktivität und β-Laktamasestabilität

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Summary

Desacetyl-cefotaxime, the main metabolite of cefotaxime, possesses a broad antibacterial spectrum. Its activity is lower than that of cefotaxime, but significantly surpasses that of cefazolin against gram-negative bacteria. The β-lactamase stability of desacetyl-cefotaxime is higher than that of the parent compound. This β-lactamase stability might be responsible for the synergistic effects of cefotaxime and desacetyl-cefotaxime occasionally seen inin vitro combination studies.

Zusammenfassung

Desacetyl-Cefotaxim, der Hauptmetabolit von Cefotaxim, besitzt ein breites Wirkungsspektrum. In seiner antibakteriellen Aktivität ist es dem Cefotaxim zwar unterlegen, übertrifft aber Cefazolin bei den gramnegativen Erregern deutlich. Die β-Laktamasestabilität von Desacetyl-Cefotaxim ist noch höher als die der Ausgangssubstanz. Diese β-Laktamasestabilität ist möglicherweise der Grund für den inin vitro Kombinationsversuchen gelegentlich nachweisbaren synergistischen Effekt von Cefotaxim und Desacetyl-Cefotaxim.

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Authors and Affiliations

  1. Hoechst AG, Postfach 80 03 20, D-6230, Frankfurt 80

    M. Limbert,  G. Seibert &  E. Schrinner

Authors
  1. M. Limbert
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  2. G. Seibert
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  3. E. Schrinner
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Limbert, M., Seibert, G. & Schrinner, E. The cooperation of cefotaxime and desacetyl-cefotaxime with respect to antibacterial activity and β-lactamase stability. Infection 10, 97–100 (1982). https://doi.org/10.1007/BF01816732

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  • DOI: https://doi.org/10.1007/BF01816732

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