Summary
The genetic polymorphism of transferrin (Tf) was studied in a sample of 385 healthy unrelated subjects of both sexes resident in the province of Cádiz (southern Spain). Isoelectric focusing was carried out in polyacrylamide gels, followed by staining with Coomassie Blue R250. The gene frequencies obtained were as follows: Tf C1, 0.7922; Tf C2, 0.1883; Tf C3, 0.0195.
Zusammenfassung
Der genetische Polymorphismus des Transferrin-Systems wurde in einer Stichprobe von 385 gesunden, unverwandten Personen beiderlei Geschlechts aus der Provinz Cádiz (Süd-Spanien) untersucht. Die isoelektrische Fokussierung wurde in Polyacrylamid-Gelen durchgeführt, die Anfärbung erfolgte mit Coomassie Blue R250. — Die erhaltenen Gen-Frequenzen waren: Tf C1 = 0,7922; Tf C2 = 0,1883; Tf C3 = 0,019.
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References
Atland K, Hackler R, Knoche W (1980) Double one dimensional electrophoresis of human serum transferrin: a new high resolution screening method for genetically determined variation. Hum Genet 54:221–231
Bargagna M, Domenici R, Giari A (1983) Distribution of Gc, Pi and Tf subtypes by isoelectric focusing in Tuscany. 10th International Congress of the Society for Forensic Haemogenetics, lectures (Society for Forensic Haemogenetics), Munich, October 11–15, pp 381–386
Carracedo A, Concheiro L (1983) Distribution of the Pi, TfC and Gc subtypes in Galicia (North West Spain). Z Rechtsmed 90: 153–158
Constans J, Kühnl P, Viau M, Spielman W (1980) A new procedure for the determination of Transferrin` (Tfc) subtypes by isoelectric focusing. Existence of two additional alleles, Tfc4 and Tfc5 Hum Genet 55:111–114
Cortivo P, Biasiolo M, Crestani C, Scorretti C, Benciolini P (1984) The polymorphism of transferrin by ultrathin-layer isoelectric focusing. If phenotypes and TfC subtypes in the population of Padua. Forensic Sci Int 24:65–68
Driesel A, Scheil H, Pfeiffer I, Rohrborm G (1981) Gene frequencies of Transferrin (TfC) subtypes in Western Germany (Düsseldorf region). Z Rechtsmed 86:133–135
Dykes DD, DeFurio CM, Polesky HF (1982) Transferrin (Tf) subtypes in US Ameridians, Whites and Blacks using thin-layer agarose gels: report on a new variant Tfc8. Electrophoresis 3: 162–164
Ferretti S, Dell'osso G, Sancasciani M, Fanetti G, Campoccia G (1988) Distribuzione della Transferrina nefla provincia di Siena. Riv It Med Leg 2:541–544
Gene M, Huguet E, Carracedo A, Ercilla G, Corbella J (1986) Frequency and distribution of Pi, Gc, Tf and PLG subtypes by isoelectric focusing in Barcelona. In: Brinkmann B, Henningsen K (eds) Advances in forensic haemogenetics, vol 1. Springer, Berlin Heidelberg New York, pp 235–239
Hjalmarsson K (1983) Distribution of Tf subtypes by isoelectric focusing in Sweden. 10th International Congress of the Society for Forensic Haemogenetics, lectures (Society for Forensic Haemogenetics), Munich, October 11–15, pp 405–409
Kamboh MI, Kirk RL (1983) Distribution of transferrin (Tf) subtypes in Asian, Pacific and Australian Aboriginal populations: evidence for the existence of a new subtype Tfc6. Hum Hered 33:237–243
Kouvatsi A, Triantaphyllidis F (1987) Gc and Tf subtypes in Greece. Hum Hered 37:62–64
Kühnl P, Constans J, Viau M, Spielmann W (1981) Isoelectric focusing of the common transferrin C allele subtypes. Electrophoresis 2:573–583
Kühnl P, Spielmann W (1978) Subtypisierung der genetisch determinierten Serumproteinpolymorphismen des Transferrins (Tf), der Gruppenspezifischen Komponente (Gc) and des α1-Anti-trypsins (Pi) mittels Isofokussierung. Arch Genet 51:15–16
Kühnl P, Spielmann W (1979) A third common allele in the Transferrin system, Tfc3 detected by isoelectric focusing. Hum Genet 50:193–198
Kühnl P, Spielmann W, Constans J (1981) Identification of seven Transferrinc allele subtypes by isoelectric focusing. Forensic Sci Int 18:297
Lucchini P, Petrucci R, Pascali V (1984) Ulteriori dati sul polimorphismo genetico della Transferrina serica in Italia: La distribuzione dei sottotipi di TfC en TfB a Firence e Catania. Riv It Med Leg 6:438–441
Nagai T, Ikeda T, Rossi G, Salviati M, Prokop O (1986) Isoelectric focusing of Ge, Tf and Pi subtypes in a Northern Italian population. In: Brinkmann B, Henningsen K (eds) Advances in forensic haemogenetics, vol 1. Springer, Berlin Heidelberg New York, pp 243–247
Parisi G, Ricci P (1985) Distribuzione del sottotipi della Transferrina C in un campione di popolazione Campana. Zacchia 3–4: 374–381
Pascali V, Auconi O (1983) Transferrin: common and rare variants in Italy. Evidence for the existence of the rare Tfc6 among Caucasians. Hum Genet 64:232–234
Rand S, Kofahl A, Brinkmann B (1986) Observations on the use of isoelectric focusing for subtyping in the transferrin (Tf) system. In: Brinkmann B, Hermingsen K (eds) Advances in forensic haemogenetics, vol 1. Springer, Berlin Heidelberg New York, pp 111–115
Smithies O (1957) Variations in human serum beta-globulins. Nature 180:1482–1483
Spik G, Bayard B, Fournet B, Strecker G, Bouquelet S, Montreuil J (1975) Studies on glycoconjugates. LXIV. Complete structure of two carbohydrate units of human serotransferrins. FEBS Lett 50:296–299
Thymann M (1978) Identification of a new serum protein polymorphism as Transferrin. Hum Genet 43:225–229
Walter H, Strodtmann H, Hilling M, Singh IP, Bhasin MK, Veerraju P (1981) Transferrin subtypes in six Indian population samples. Hum Hered 31:152–155
Weidinger S, Cleve H, Schwarzfischer F, Portel W, Weser J, Gorg A (1984) Transferrin subtypes and variants in Germany; further evidence for a Tf null allele. Hum Genet 66:356–360
Yuasa I, Saneshige Y, Okamoto N, Ikawa S, Hikita T, Ikebuchi J, Inoue T, Okada K (1983) Distribution of Hp, Tf, Gc and Pi polymorphisms in a Nepalese population. Hum Hered 33:302–306
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Gamero, J.J., Romero, J.L., Vizcaya, M.A. et al. Transferrin gene frequencies in Cádiz (southern Spain). Int J Leg Med 104, 17–19 (1990). https://doi.org/10.1007/BF01816478
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DOI: https://doi.org/10.1007/BF01816478