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Cyclical use of tamoxifen and high-dose medroxyprogesterone acetate in advanced estrogen receptor positive breast cancer

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Summary

One-hundred and seventy patients with estrogen receptor positive (≥10 pmol/g protein) advanced breast cancer have been treated in a prospective randomized study either with continuous tamoxifen 30 mg × 1 daily (TAM), or with TAM 30 mg × 1 daily for 8 weeks alternating with medroxyprogesterone acetate 500 mg × 2 daily for 8 weeks (TAM/HD-MPA). The response rate was 62% in the group treated with cyclic TAM/HD-MPA versus 41% in the TAM alone group (p = 0.02). There was no significant difference in duration of remissions or survival.

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Authors and Affiliations

  1. Department of Medical Oncology and Radiotherapy, The Norwegian Radium Hospital, 0310, Montebello, Oslo 3, Norway

    S. Gundersen & H. Høst

  2. Department of Medical Oncology and Radiotherapy, Regional and University Hospital Trondheim, 7006, Trondheim, Norway

    S. Kvinnsland & O. Klepp

  3. Department of Therapeutic Oncology and Radiophysics, University of Bergen, 5021, Haukeland, Bergen, Norway

    S. Lundgren

  4. Department of Medical Oncology and Radiotherapy, Office for Clinical Investigations, The Norwegian Radium Hospital, 0310, Montebello, Oslo 3, Norway

    E. Lund

  5. Central Laboratory, The Norwegian Radium Hospital, 0310, Montebello, Oslo 3, Norway

    O. Børmer

Authors
  1. S. Gundersen
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  2. S. Kvinnsland
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  3. S. Lundgren
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  4. O. Klepp
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  5. E. Lund
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  6. O. Børmer
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  7. H. Høst
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Gundersen, S., Kvinnsland, S., Lundgren, S. et al. Cyclical use of tamoxifen and high-dose medroxyprogesterone acetate in advanced estrogen receptor positive breast cancer. Breast Cancer Res Tr 17, 45–50 (1990). https://doi.org/10.1007/BF01812683

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  • DOI: https://doi.org/10.1007/BF01812683

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