Breast Cancer Research and Treatment

, Volume 17, Issue 1, pp 15–21 | Cite as

Tissue polypeptide antigen in tumor cytosol: A new prognostic indicator in primary breast cancer

  • Massimo Gion
  • Riccardo Mione
  • Carlo Gatti
  • Ruggero Dittadi
  • Antonette Leon
  • Cristina Castiglioni
  • Ottorino Nascimben
  • Giuliano Bruscagnin
Report

Summary

The assessment of the risk of relapse is a critical need in the management strategy of breast cancer patients. To date, the most reliable prognostic factor is axillary nodal status. Several other pathological and biological parameters are currently under evaluation.

Since 1982 we have been studying the prognostic role of several tumor markers in breast cancer cytosol. Elevated cytosol concentrations of tissue polypeptide antigen (TPA) have been found to have a highly significant direct correlation with both prolonged relapse-free interval (RFI) and higher survival rate.

The information provided by cytosol TPA was independent of both axillary nodal status and steroid receptor content. In patients with a low risk of relapse (no axillary metastases, estrogen and progesterone receptor positive), cytosol TPA was still a significant prognostic indicator.

Key words

breast cancer cytosol prognosis tissue polypeptide antigen tumor markers 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Massimo Gion
    • 3
  • Riccardo Mione
    • 3
  • Carlo Gatti
    • 3
  • Ruggero Dittadi
    • 3
  • Antonette Leon
    • 3
  • Cristina Castiglioni
    • 1
    • 3
  • Ottorino Nascimben
    • 2
    • 3
  • Giuliano Bruscagnin
    • 3
  1. 1.2nd Division of SurgeryRegional General HospitalMestreItaly
  2. 2.Oncology CenterRegional General HospitalMestreItaly
  3. 3.Division of Radiotherapy and Nuclear MedicineOncology Center, Regional General HospitalVeniceItaly

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