3-Methyladipate excretion in animals fed a phytol supplement with reference to Refsum's disease

  • S. Krywawych
  • D. P. Brenton
  • M. J. Jackson
  • C. Forte
  • D. K. Walker
  • A. M. Lawson
Short Communication

Keywords

Public Health Internal Medicine Metabolic Disease Phytol 

References

  1. Baxter, J. H., Steinberg, D., Mize, C. E. and Avigan, J. Absorption and metabolism of uniformly14C labeled phytol and phytanic acid by the intestine of the rat studied with thoracic duct canulation.Biochim. Biophys. Acta 137 (1967) 227–290Google Scholar
  2. Bjorkhem, I. On the mechanism of ω-oxidation of fatty acids.J. Biol. Chem. 251 (1976) 5219–5266PubMedGoogle Scholar
  3. Brenton, D. P. and Krywawych, S. 3-Methyladipate excretion in Refsum's disease.Lancet 1 (1982) 624Google Scholar
  4. Chalmers, R. A. and Watts, R. W. E. The quantitative extraction and gas liquid chromatographic determination of organic acids in urine.Analyst 97 (1972) 958–967PubMedGoogle Scholar
  5. Pettersen, J. E. Formation ofn-hexandioic acid from hexadecanoic acid by initial ω-oxidation in ketotic rats.Clin. Chim. Acta 41 (1972) 231–237PubMedGoogle Scholar
  6. Sahgal, V. and Olsen, W. O. Heredopathia atactica polyneuritiformis (phytanic acid storage disease). A new case with special reference to treatment.Arch. Int. Med. 135 (1975) 585–587Google Scholar
  7. Steinberg, D., Mize, C. E., Herndon Jr, J. H., Fales, H. M., Engel, W. K. and Vroom, F. Q. Phytanic acid in patients with Refsum's syndrome and response to dietary treatment.Arch. Int. Med. 125 (1970) 75–87Google Scholar

Copyright information

© SSIEM and MTP Press Limited 1985

Authors and Affiliations

  • S. Krywawych
    • 1
  • D. P. Brenton
    • 1
  • M. J. Jackson
    • 1
  • C. Forte
    • 1
  • D. K. Walker
    • 1
  • A. M. Lawson
    • 2
  1. 1.Department of MedicineUniversity College London School of Medicine, The Rayne InstituteLondonUK
  2. 2.M.R.C. Clinical Research Centre Mass Spectrometry UnitHarrowUK

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