Summary
Our previous work showed urinary androgen excretion (A) as well as estrogen receptor (ER) to predict clinical response and survival after ovariectomy for advanced breast cancer. We here compare the complete responders with the partial responders to ovariectomy. The likelihood of CR (55% of responders) rather than PR was not strongly dependent on the location of metastases or on the ER/A status (though as noted previously there were no responses at all in the ER-/A- group), but CR did appear to increase survival.
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References
Oriana S, Secreto G, Di Fronzo G, Torri A: Urinary androgens and tumor estrogen receptor as predictors of ovariectomy response and of survival in advanced breast cancer. Breast Cancer Res Treat 9: 201–205, 1987
Pedrazzini A, Cavalli F, Brunner KW, Goldhirsch A, Mermillod B: Complete remission following endocrine or combined cytotoxic and hormonal treatment in advanced breast cancer. A retrospective analysis. Oncology 44: 51–59, 1987
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Presented as an abstract at the 10th Annual Breast Cancer Symposium, San Antonio, Texas, December 11–12, 1987
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Oriana, S., Secreto, G., Di Fronzo, G. et al. Complete remission after ovariectomy for advanced breast cancer correlated with estrogen receptor status and urinary androgen excretion. Breast Cancer Res Tr 12, 303–305 (1988). https://doi.org/10.1007/BF01811243
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DOI: https://doi.org/10.1007/BF01811243