Breast Cancer Research and Treatment

, Volume 14, Issue 2, pp 201–206 | Cite as

Megestrol acetate versus aminoglutethimide for metastatic breast cancer

  • S. Lundgren
  • S. Gundersen
  • R. Klepp
  • P. E. Lønning
  • E. Lund
  • S. Kvinnsland


In this prospective, randomized study the clinical response and toxicity of megestrol acetate (MA) and aminoglutethimide (AG) as second-line treatment in patients with metastatic breast cancer was compared. 176 patients were included, and 150 received treatment>8 weeks and are evaluable for treatment response. The two groups did not differ with regard to prognostic factors. Response rate for the AG and MA groups were 34% and 31% respectively, with duration of response of 13.1 and 13.0 months. Stable disease was obtained in 33% and 35% respectively. No difference was observed in survival. Side effects occurred more frequently in the AG group (42%) than in the MA group (18%).

Key words

advanced breast cancer second-line endocrine therapy megestrol acetate aminoglutethimide 


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • S. Lundgren
    • 1
  • S. Gundersen
    • 2
  • R. Klepp
    • 3
  • P. E. Lønning
    • 1
  • E. Lund
    • 2
  • S. Kvinnsland
    • 1
    • 3
  1. 1.Department of Medical Oncology and RadiotherapyUniversity of BergenNorway
  2. 2.Department of Medical Oncology and RadiotherapyThe Norwegian Radium HospitalMontebelloNorway
  3. 3.Department of Medical Oncology and RadiotherapyThe Regional and University Hospital in TrondheimTrondheimNorway

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