Skip to main content

Glucose tolerance test in the Ainu


In an attempt to find out specific characteristics in carbohydrate metabolism in the Ainu, if any, glucose tolerance test was carried out. Between the Ainu and non-Ainu Japanese no differences were observed in the blood glucose, immunoreactive insulin and human growth hormone levels in the plasma after glucose load. Fasting levels of plasma FFA were significantly lower in the Ainu than in the Japanese. Changes in the FFA after glucose load were less in the Ainu, while the Japanese showed a marked rebound of the plasma FFA.


Der Glukosetoleranztest wurde bei 10 Ainu und 20 Japanern (Studenten) durchgeführt. Signifikante Unterschiede im Blutzucker, immunreaktiven Insulin und humanen Wachstumshormon im Plasma wurden nach der Glukosegabe nicht gefunden. Die Nüchternwerte der freien Fettsäuren waren in den Ainu signifikant tiefer als bei den Japanern. Die Aenderungen der freien Fettsäuren nach Glukose waren bei den Ainu geringer, während die Japaner einen ausgeprägten "rebound effect" aufwiesen.


On a appliqué un test de tolérance à la glucose à 10 Aïnous et à 20 Japonais d'autres races (tous étudiants). On n'a pas décelé de différence significative après administration de glucose ni dans la teneur en sucre du sang, ni dans le taux d'insuline immunoréactive, ni dans les hormones humaines de croissance contenues dans le plasma. Les coefficients d'acides gras libres (FFA), après un jeûne ont été plus bas chez les Aïnous que chez les Japonais et cela de façon significative. La modification des acides gras libres après administration de glucose a été moins marquée chez les Aïnous alors que les Japonais présentaient un net "effet de rebondissement".

This is a preview of subscription content, access via your institution.


  • BOLLINGER, R.E., SHANE, S.R. and KIRKPATRICK, C.H. (1962): Secondary rise in plasma free fatty acids following glucose load. J.clin.Endocr., 22: 873–878.

    PubMed  Google Scholar 

  • HALES, C.N., Jr. and RANDLE, P.J. (1963): Effects of low carbohydrate diet and diabetes mellitus on plasma concentrations of glucose, non-esterified fatty acid, and insulin during oral glucose tolerance tests. Lancet 1, 790–794.

    PubMed  Google Scholar 

  • HOFFMAN, W.S. (1937): A rapid photoelectric method for the determination of glucose in blood and urine. J.biol.Chem., 120: 51–55.

    Google Scholar 

  • ITAYA, K. and UI, M. (1965): Colorimetric determination of free fatty acids in biological fluids. J. lipid Res., 6: 16–20.

    Google Scholar 

  • ITOH, S., KUROSHIMA, A., DOI, K., MORIYA, K., SHIRATO, H. and YOSHIMURA, K. (1969): Lipid metabolism in relation to cold adaptability in man. Fed. Proc., 28: 960–964.

    PubMed  Google Scholar 

  • MORGAN, C.R. and LAZAROW, A. (1963): Immunoassay of insulin: Two antibody system. Diabetes, 12: 115–126.

    Google Scholar 

  • NESTEL, P.J., CARROLL, K.F. and SILVERSTEIN, M.S. (1964): Influence of free fatty acid metabolism on glucose tolerance. Lancet 2, 115–117.

    Google Scholar 

  • RANDLE, P.J., GARLAND, P.B., HALES, C.N. and NEWHOLME, E.A. (1963): The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785–789.

    PubMed  Google Scholar 

  • SCHALCH, D.S. and KIPNIS, D.M. (1965): Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids. J.clin.Invest., 44: 2010–2020.

    PubMed  Google Scholar 

  • SCHALCH, D.S. and PARKER, M.L. (1964): A sensitive double antibody immunoassay for human growth hormone in plasma. Nature (Lond.), 203: 1141–1142.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kuroshima, A., Itoh, S., Azuma, T. et al. Glucose tolerance test in the Ainu. Int J Biometeorol 16, 193–197 (1972).

Download citation

  • Received:

  • Issue Date:

  • DOI: