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Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus

Acta Neurochirurgica volume 106, pages 9–12 (1990)Cite this article

Summary

Fourteen patients with normal pressure hydrocephalus had the autoregulation of cerebral blood flow (CBF) and intracranial pressure (ICP) investigated. In 8 of the patients the effect of Captopril on ICP and CBF was also investigated. The mean arterial blood pressure (MABP) was 109 mmHg (intra-arterially), and ICP was 11 mmHg (intraventricularly). Changes in global CBF were estimated by the arterio-venous oxygen difference method. The autoregulation of CBF was present in 13 of the patients (p < 0.01). The lower limit of CBF autoregulation was 86% of the baseline perfusion pressure. One hour after 50 mg of captopril perorally, MABP was reduced 16 mmHg, and ICP and CBF were unchanged. The autoregulation was maintained and the lower limit was decreased 19 mmHg. Thus patients would be expected to benefit from captopril treatment in hypotensive anaesthesia.

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Affiliations

  1. Rigshospitalet, University Clinic of Neurosurgery, Copenhagen, Denmark

    A. R. Andersen

  2. Rigshospitalet, University Clinic of Neurology, Copenhagen, Denmark

    O. B. Paulson

  3. Department of Anesthesiology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark

    J. F. Schmidt M.D., A. R. Andersen, O. B. Paulson & F. Gjerris

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  1. J. F. Schmidt M.D.
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  2. A. R. Andersen
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  3. O. B. Paulson
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  4. F. Gjerris
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Schmidt, J.F., Andersen, A.R., Paulson, O.B. et al. Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus. Acta neurochir 106, 9–12 (1990). https://doi.org/10.1007/BF01809326

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  • DOI: https://doi.org/10.1007/BF01809326

Keywords

  • Intracranial pressure
  • cerebral blood flow
  • autoregulation
  • angiotensin converting enzyme inhibition