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Breast Cancer Research and Treatment

, Volume 16, Issue 2, pp 111–117 | Cite as

Steroid hormone receptor levels and adjuvant tamoxifen in early breast cancer

Ten year results of the Naples (GUN) study
  • Sabino De Placido
  • Ciro Gallo
  • Alfredo Marinelli
  • Francesco Perrone
  • Clorindo Pagliarulo
  • Giuseppe Petrella
  • Giovanni Delrio
  • Michela D'Istria
  • Lucia Del Mastro
  • Angelo Raffaele Bianco
Report

Summary

Ten year disease-free survival (DFS) results of the Naples randomized trial of adjuvant tamoxifen (TM), 30 mg per day for 2 years versus no therapy according to receptor levels, are reported. From Feb. 1, 1978, through Dec. 31, 1983, 308 pre- and postmenopausal patients with early breast cancer entered the trial. Estrogen receptor (ER) data were available on 239 (77.6%) patients, progesterone receptor (PgR) data on 194 (63.0%), and both receptor data on 181 (58.8%).

ER and PgR were assayed by dextran-coated charcoal technique in a single laboratory. The effect of adjuvant TM was significantly related to ER and PgR concentration of the primary tumor. The greatest TM benefit on DFS was evident in patients with the highest levels of receptors. The interaction between the treatment effect and receptor concentration was found whether ER and PgR were considered separately or together.

Key words

adjuvant therapy breast cancer endocrine therapy estrogen receptor progesterone receptor tamoxifen 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Sabino De Placido
    • 1
  • Ciro Gallo
    • 2
  • Alfredo Marinelli
    • 1
  • Francesco Perrone
    • 1
  • Clorindo Pagliarulo
    • 1
  • Giuseppe Petrella
    • 3
  • Giovanni Delrio
    • 4
  • Michela D'Istria
    • 4
  • Lucia Del Mastro
    • 1
  • Angelo Raffaele Bianco
    • 1
  1. 1.Division of Medical OncologyUniversity of Naples Medical School IINaplesItaly
  2. 2.Institute of Health StatisticsUniversity of Naples Medical School INaplesItaly
  3. 3.Division of Surgical OncologyUniversity of Naples Medical School IINaplesItaly
  4. 4.Department of BiologyUniversity of Naples Medical School INaplesItaly

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