Breast Cancer Research and Treatment

, Volume 16, Issue 2, pp 97–102 | Cite as

Estimation of epidermal growth factor receptor in 177 breast cancers: Correlation with prognostic factors

  • M. Bolla
  • M. Chedin
  • C. Souvignet
  • J. Marron
  • C. Arnould
  • E. Chambaz
Report

Summary

Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation.

Key words

breast cancer EGF receptor estrogen receptor histologic grade progesterone receptors 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • M. Bolla
    • 1
  • M. Chedin
    • 2
  • C. Souvignet
    • 2
  • J. Marron
    • 1
  • C. Arnould
    • 2
  • E. Chambaz
    • 2
  1. 1.Radiotherapy DepartmentGrenoble CedexFrance
  2. 2.Biochemistry Department Centre Hospitalo-Universitaire Albert MichallonGrenoble CedexFrance

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