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Cerebral blood flow during increased subarachnoid pressure

The influence of systemic arterial pressure

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Summary

In rhesus monkeys and cats cerebral intracranial pressure was increased by intracranial fluid injection. Increased liquor pressure was transferred to the superficial cerebral veins, which caused a reduction of cerebral perfusion pressure. An arterial pressure response occurred as soon as the perfusion pressure was less than 100 mm Hg. The pressure increase was dependent on the percent rate of perfusion pressure decrease in relation to the systemic arterial pressure. Carotid flow measured in monkeys showed a slight reduction as long as the perfusion pressure was higher than 50 mm Hg but was marked when it fell below that value. The systemic arterial pressure had a significant influence on cerebral vessel resistance independent from the perfusion pressure. During increased intracranial pressure the cerebral blood volume seemed to be moderately decreased.

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Author notes

  1. F. Matakas

    Present address: Department of Neuropathology, Klinikum Steglitz der Freien Universität Berlin, Deutschland

  2. J. Franke

    Present address: Department of Nuclear Medicine, Klinikum Steglitz der Freien Universität Berlin, Deutschland

  3. M. Leipert

    Present address: Universitäts-Nervenklinik, Osianderstraße 22, D-74, Tübingen, Germany

Authors and Affiliations

  1. Department of Neuropathology, Klinikum Steglitz der Freien Universität Berlin, Deutschland

    M. Leipert & J. Franke

  2. Department of Nuclear Medicine, Klinikum Steglitz der Freien Universität Berlin, Deutschland

    F. Matakas &  M. Leipert

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  1. F. Matakas
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  3. J. Franke
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Matakas, F., Leipert, M. & Franke, J. Cerebral blood flow during increased subarachnoid pressure. Acta neurochir 25, 19–36 (1971). https://doi.org/10.1007/BF01808860

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