Abstract
Reaction of diiminosuccinonitrile (DISN) with 3′-AMP in the presence of alkali- and alkaline earth-montmorillonites results in the formation of 2′,3′-cAMP in aqueous solution. Little or no 2′,3′-cAMP is produced when metal ion concentrations equivalent to that of the metal ion associated with the homoionic clays are used instead of mobntmorillionite. Yields comparable to those obtained with DISN are obtained when diaminomaleonitrile (DAMN) is used in place of DISN as the condensing agent. DAMN, a compound which is more stable than DISN in aqueous solution, is oxidized to DISN on the surface of the clay by Fe+3 in the clay lattice. DISN, the true condensing agent, is thus generated in the presence of the bound 3′-AMP on the montmorillonite surface. The montmorillonite catalyzes the DISN-mediated formation of 2′,3′-cAMP and this product, which binds much less strongly than does the 3′-AMP, is desorbed from the clay surface. This research established that the montmorillonite performs four different functions in its role as catalyst: (1) Binding one of the substrate molecules (3′-AMP) (2) Activating the second substrate (DAMN) (3) Catalyzing the formation of 2′,3′-cAMP (4) Releasing the reaction product so another substrate molecules can bind to the montmorillonite.
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References
Acevedo, O. and Orgel, L. E.: 1986,Origins of Life 16 441.
American Petroleum Institute: 1951, Clay Mineral Standards. American Petroleum Institute, Project 49, Preliminary Report 7B, Chemical Analysis, Columbia University, New York.
Aronowitz, S., Coyne, L., Lawless, J., and Rishpon, J.: 1982,Inorg. Chem. 21 3589.
Banin, A. and Rishpon, J.: 1979,J. Mol. Evol. 14 133.
Banin, A., Lawless, J. G., Mazzurco, J., Church, F. M., Margulies, L., and Orenberg, J. B.: 1985,Origins of Life 15 89.
Bernal, J. D.: 1949,Proc. Roy. Soc. 62A 537.
Brack, A. L.: 1976,Clay Minerals 11 117.
Braterman, P. S., Cairns-Smith, A. G., and Sloper, R.: 1983,Nature 303 163.
Cairns-Smith, A. G.: 1982, ‘Genetic Takeover’, Cambridge University Press, Cambridge, Great Britain.
Ferris, J. P., Edelson, E. H., Mount, N. M., and Sullivan, A. E.: 1979,J. Mol. Evol. 13 317.
Ferris, J. P., Hagan, W. J., Jr., Alwis, K. W., and McCrea, J.: 1982,J. Mol. Evol. 18 304.
Ferris, J. P. and Hagan, W. J.: 1984,Tetrahedron 40 1093.
Ferris, J. P., Yanagawa, H., Dudgeon, P. A., Hagan, W. J., Jr., and Mallare, T. E.: 1984,Origins of Life 15 29.
Ferris, J. P. and Hagan, W. J.: 1986,Origins of Life 17 69.
Ferris, J. P., Huang, C.-H., and Hagan, W. J., Jr.: 1986,Origins of Life 16 473.
Fox, S. W. and Dose, K.: 1972,Molecular Evolution and the Origin of Life, Marcel Dekker, New York.
Hagan, W. J., Jr.: 1985, Ph.D. Thesis, RPI.
Holm, N. G.: 1985,Origins of Life 15 131.
Inoue, T. and Orgel, L. E.: 1982,J. Mol. Biol. 162 201.
Joe, H., Kuma, K., Paplawsky, W., Rea, B., and Arrhenius, G.: 1986,Origins of Life 16 369.
Lawless, J. G., Banin, A., Church, F. M., Mazzurco, J., Huff, R., Kao, J., Cook, A., Lowe, T., Orenberg, J. B., and Edelson, E.: 1985,Origins of Life 15 77.
Miller, S. L. and Parris, M.: 1964,Nature 204 1248.
Paecht-Horowitz, M.: 1976,Origins of Life 7 369, and references therein.
Rao, M., Odom, D. G., and Oro, J.: 1980,J. Mol. Evol. 15 317.
Sanchez, R. A., Ferris, J. P., and Orgel, L. E.: 1967,J. Mol. Biol. 30 223.
Schwartz, A. W. and Orgel, L. E.: 1985,J. Mol. Evol. 21 299.
Schwartz, A. W.: 1986,Origins of Life 16 444.
Usher, D. A. and Yee, D.: 1979,J. Mol. Evol. 13 287.
Verlander, M. S., Lohrman, R., and Orgel, L. E.: 1973,J. Mol. Evol. 2 303.
Verlander, M. S. and Orgel, L. E.: 1974,J. Mol. Evol. 3 115.
Warden, J. T., McCullough, J. J., Lemmon, R. M., and Calvin, M.: 1974,J. Mol. Evol. 4 189.
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Ferris, J.P., Huang, CH. & Hagan, W.J. Montmorillonite: A multifunctional mineral catalyst for the prebiological formation of phosphate esters. Origins Life Evol Biosphere 18, 121–133 (1988). https://doi.org/10.1007/BF01808786
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DOI: https://doi.org/10.1007/BF01808786