Acta Neurochirurgica

, Volume 131, Issue 3–4, pp 226–228 | Cite as

The risk of cancer in relatives of patients with brain neoplasm

  • D. Sakas
  • N. Kalfakis
  • M. Panas
  • D. Vassilopoulos
  • P. Carvounis
Clinical Articles


The family trees of 142 patients, suffering from histologically proven brain tumour, were compared to those of an equal number of sex and age matched controls. The results showed no statistically significant differences in the occurrence of malignant neoplasm between the two groups. These results indicate that the risk of cancer among relatives of patients with brain tumours does not exceed that of healthy controls.


Brain tumour family genetics 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Armstrong RM, Hanson CW (1969) Familial gliomas. Neurology 19: 1061–1063PubMedGoogle Scholar
  2. 2.
    Bellur SN, Chandra V, McDonald LW (1979) Association of meningiomas with extraneural primary malignancies. Neurology 29: 1165–1168PubMedGoogle Scholar
  3. 3.
    Challa VR, Goodman HO, Daris CH (1983) Familial brain tumours: Studies of two families and review of the recent literature. Neurology 12: 18–23Google Scholar
  4. 4.
    Delleman JW, De Jong JGY, Bleeker GM (1978) Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neurinomas. Neurology 28: 567–570PubMedGoogle Scholar
  5. 5.
    Draper GJ, Heaf MM; Kinnier Wilson LM (1977) Occurrence of childhood cancers among sibs and estimation of familial risks. J Med Genet 14: 81–90PubMedGoogle Scholar
  6. 6.
    Hartley AL, Birch JM, Marsden HB, Reid H, Harris M, Blair V (1987) Adrenal cortical tumors: epidemiological and familial aspects. Arch Dis Child 62: 683–689PubMedGoogle Scholar
  7. 7.
    Kitchin FD, Ellsworth RM (1974) Pleiotropic effects of the gene for retinoblastoma. J Med Genet 11: 244–246PubMedGoogle Scholar
  8. 8.
    Knudson AJ (1986) Genetics of human cancer. Ann Rev Genet 20: 231–252PubMedGoogle Scholar
  9. 9.
    Meadows AT, D'Angio GJ, Mike V, Banfi A, Harris C, Jenkins RDT, Schwartz A (1977) Patterns of second malignant neoplasms in children. Cancer 40: 1901–1911Google Scholar
  10. 10.
    Pelgrom von Motz IJ, Bots AM, Endtz LJ (1977) Astrocytoma in three sisters. Neurology 27: 1038–1041PubMedGoogle Scholar
  11. 11.
    Schimke RN (1990) Cancer genetics. In: Emery AEH, Rimoin DL (eds) Principle and practice of medical genetics. Churchill Livingstone, Edinburgh, pp1881–1908Google Scholar
  12. 12.
    Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies in other sites. Neurology 25: 705–712PubMedGoogle Scholar
  13. 13.
    Schoenberg BS, Gista GG, Reagan TJ (1975) The familial occurrence of glioma. Surg Neurol 3: 139–145PubMedGoogle Scholar
  14. 14.
    Schoenberg BS (1991) Epidemiology of primary intracranial neoplasms. Disease distribution and risk factors. In: Salcman M (ed) Neurobiology of brain tumors. Williams and Wilkins, Baltimore, pp3–18Google Scholar
  15. 15.
    Slowik E, Jellinger K (1990) Association of primary cerebral lymphoma with meningioma: report of two cases. Clin Neuropath 9: 69–73Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • D. Sakas
    • 1
  • N. Kalfakis
    • 1
  • M. Panas
    • 1
  • D. Vassilopoulos
    • 1
  • P. Carvounis
    • 2
  1. 1.Department of NeurologyAthens National University, Eginition HospitalAthensGreece
  2. 2.Department of NeurosurgeryAthens National University, Evangelismos HospitalAthensGreece

Personalised recommendations