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Medulloblastoma in adulthood: Prognostic factors influencing survival and recurrence

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Summary

Thirty adult patients presenting with medulloblastoma between 1974 and 1991 were studied and treated at Puerta de Hierro Clinic. After diagnosis, all patients were treated by surgery followed by radiotherapy and eight of them received adjuvant chemotherapy. We have studied the influence of some factors such as age, sex, location of tumour in the cerebellum, amount of surgical resection and histological variants on survival and recurrence of the disease. Only the histological type has a statistically significant influence on survival and recurrence: we have found that patients presenting classic medulloblastoma have a long survival and a long relapse-free interval.

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References

  1. Bailey P, Cushing H (1925) Medulloblastoma cerebelli. A common type of midcerebellar glioma of childhood. Arch Neurol Psychiatry 14: 192–224

    Google Scholar 

  2. Berry MP, Jenkin RDT, Keen CW, Nair BD, Simpson WJ (1981) Radiation treatment for medulloblastoma. J Neurosurg 55: 43–51

    PubMed  Google Scholar 

  3. Caputy AJ, McCullough DC, Manz HJ, Patterson K, Hammock MK (1987) A review of factors influencing the prognosis of medulloblastoma. J Neurosurg 66: 80–87

    PubMed  Google Scholar 

  4. Choux M, Lena G (1982) Le médulloblastome. Neurochirurgie [Suppl 1] 28: 1–229

    Google Scholar 

  5. Cornu P, Chatellier G, Fauchon F, Foncin JF, Faillot T, Dorwling-Carter D, Philippon J (1990) Pronostic des médulloblastomes de l'adulte. Neurochirurgie 36: 218–224

    PubMed  Google Scholar 

  6. Cox DR (1972) Regression models and life-tables (with discussion). J R Stat Soc (B) 34: 187–220

    Google Scholar 

  7. Ferrante L, Mastronardi L, Celli P, Acqui M, Cervoni L, Fortuna A (1991) Medulloblastoma in adulthood. J Neurosurg Sci 35: 23–30

    PubMed  Google Scholar 

  8. Garton GR, Schomberg PJ, Scheithauer BW, Shaw EG, Ilstrup DM, Blackwell CR, Laws ER, Earle JD (1990) Medulloblastoma-Prognostic factors and outcome of treatment: review of the Mayo Clinic experience. Mayo Clin Proc 65: 1077–1086

    PubMed  Google Scholar 

  9. Gaspar LE, Dawson DJ, Tilley-Gulliford SA, Banerjee P (1991) Medulloblastoma: long-term follow-up of patients treated with electron irradiation of the spinal field. Radiology 180: 867–870

    PubMed  Google Scholar 

  10. Gehan EA (1965) A generalized Wilcoxon test for comparing arbitrarily singly censored samples. Biometrika 52: 203–233

    PubMed  Google Scholar 

  11. Hubbard JL, Scheithauer BW, Kispert DB, Carpenter SM, Wick MR, Laws ER (1989) Adult cerebellar medulloblastomas: the pathological, radiographic, and clinical disease spectrum. J Neurosurg 70: 536–544

    PubMed  Google Scholar 

  12. Hughes PG, Hughes MB, Hughes FRCS, Hughes FRCR (1984) Cerebellar medulloblastomas in adults. J Neurosurg 60: 994–997

    PubMed  Google Scholar 

  13. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481

    Google Scholar 

  14. Muller W, Afra D, Schröder R, Slowik F, Wilcke O, Klug N (1982) Medulloblastomas: survey of factors possibly influencing the prognosis. Acta Neurochir (Wien) 64: 215–224

    Google Scholar 

  15. Packer RJ (1990) Chemotherapy for medulloblastoma/primitive neuroectodermal tumours of the posterior fossa. Ann Neurol 28: 823–828

    PubMed  Google Scholar 

  16. Pobereskin L, Treip C (1986) Adult medulloblastoma. J Neurol Neurosurg Psychiatry 49: 39–42

    PubMed  Google Scholar 

  17. Seitz WS, Operschall EJ (1987) Medulloblastoma: example of late adult onset with statistical correlation relative to etiology. Radiol Clin 47: 295–309

    Google Scholar 

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Aragonés, M.P., Magallón, R., Piqueras, C. et al. Medulloblastoma in adulthood: Prognostic factors influencing survival and recurrence. Acta neurochir 127, 65–68 (1994). https://doi.org/10.1007/BF01808549

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