Catalysis of the oligomerization of O-phospho-serine, aspartic acid, or glutamic acid by cationic micelles

  • Christof Böhler
  • Aubrey R. HillJr.
  • Leslie E. Orgel


Treatment of relatively concentrated aqueous solutions of O-phospho-serine (50 mM), aspartic acid (100 mM) or glutamic acid (100 mM) with carbonyldiimidazole leads to the formation of an activated intermediate that oligomerizes efficiently. When the concentration of amino acid is reduced tenfold, few long oligomers can be detected. Positively-charged cetyltrimethyl ammonium bromide micelles concentrate the negatively-charged activated intermediates of the amino acids at their surfaces and catalyze efficient oligomerization even from dilute solutions.


Ammonium Aqueous Solution Bromide Organic Chemistry Catalysis 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Christof Böhler
    • 1
  • Aubrey R. HillJr.
    • 1
  • Leslie E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA

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