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Adjuvant chemo-endocrine therapy for androgen-dependent mammary tumor in mice

  • US-Japan Conference on Chemoendocrine Therapy
  • Published:
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Summary

About 500 male DS mice grafted with androgen-dependent Shionogi carcinoma 115 (SC115) were used. When the tumor diameter reached about 20 mm (approximately 25 days after transplantation), excision of the tumor and/or castration were carried out. The injection of cyclophosphamide (80 mg/kg body weight × 3 at 7-day intervals) was started from the day after excision.

In mice with excised tumor, adjuvant chemo-endocrine therapy was the most effective treatment examined; cumulative 120-day mortalities after transplantation of tumors in non-treated, adjuvant endocrine therapy, adjuvant chemotherapy and adjuvant chemo-endocrine therapy groups were 91%, 29%, 21% and 0%, respectively. Castration induced development of clusters of androgen-independent cancer cells in androgendependent SC115 tumor. In mice without tumor excision, the chemo-endocrine therapy was again the most effective treatment, though 86% of mice died by the 120th day after tumor transplantation. These findings suggest the usefulness of adjuvant chemo-endocrine therapy for achieving complete remission in hormonedependent tumors.

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Authors and Affiliations

  1. Shionogi Research Laboratory, Shionogi & Co., Ltd., 553, Fukushima-ku, Osaka, Japan

    Naomi Uchida & Kenji Yamaguchi

  2. Departments of Surgery, Osaka University Medical School, 530, Kita-ku, Osaka, Japan

    Norihiko Narita & Kazuyasu Nakao

  3. Pathology, Osaka University Medical School, 530, Kita-ku, Osaka, Japan

    Keishi Matsumoto

  4. Institute for Cancer Research, Osaka University Medical School, 530, Kita-ku, Osaka, Japan

    Yukihiko Kitamura

Authors
  1. Naomi Uchida
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  2. Kenji Yamaguchi
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  3. Norihiko Narita
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  4. Kazuyasu Nakao
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  5. Yukihiko Kitamura
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  6. Keishi Matsumoto
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Additional information

Address for reprints: K. Matsumoto, M.D., Dept. of Pathology, Osaka University, Medical School, Kita-ku, Osaka 430, Japan.

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Uchida, N., Yamaguchi, K., Narita, N. et al. Adjuvant chemo-endocrine therapy for androgen-dependent mammary tumor in mice. Breast Cancer Res Tr 1, 69–75 (1981). https://doi.org/10.1007/BF01807894

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