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Androgen metabolism and apocrine differentiation in human breast cancer

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Summary

Metabolism of (7α-3H) testosterone has been measured in 111 human breast cancers and compared retrospectively with the degree of apocrine differentiation in the tumors. Cancers in which apocrine characteristics were a marked feature metabolized significantly more testosterone precursor than those in which apocrine features did not predominate. Higher metabolism was accounted for by increased conversion to 5α-reduced products such as 5α-dihydrotestosterone and 5α-androstanediols.

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Authors and Affiliations

  1. University Department of Clinical Surgery, Royal Infirmary, EH3 9YW, Edinburgh, United Kingdom

    W. R. Miller, J. Telford & J. M. Dixon

  2. University Department of Pathology, Royal Infirmary, Edinburgh, United Kingdom

    A. A. Shivas

Authors
  1. W. R. Miller
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  2. J. Telford
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  3. J. M. Dixon
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  4. A. A. Shivas
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Miller, W.R., Telford, J., Dixon, J.M. et al. Androgen metabolism and apocrine differentiation in human breast cancer. Breast Cancer Res Tr 5, 67–73 (1985). https://doi.org/10.1007/BF01807652

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