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Progesterone binding cyst protein (PBCP) in primary breast cancer: A new prognostic factor?

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Summary

Different secretory proteins have been evaluated as possible tumor markers in breast cancer. In this study progesterone binding cyst protein (PBCP) has been quantitated in breast tumor tissue. We report on a correlation of PBCP in cytosols of primary breast cancer, with known prognostic factors. A significant difference (p < 0.001, Chi-square) in the frequency of PBCP-negative patients in clinical Stage I and Stage II is found. This was mainly attributed to a difference between T1 and T2 tumors, with less contribution from nodal status. A biological function of PBCP in breast cancer is not known. The distribution of PBCP in our patients has a close resemblance with expected number of node positive patients, suggesting that PBCP as a tumor marker may aid in providing prognostic information in breast cancer patients.

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Authors and Affiliations

  1. Department of Surgery, University of Bergen, 5016 Haukeland Sykehus, Bergen, Norway

    Jon Arne Søreide

  2. Oncology Research Laboratory, University of Bergen, Bergen, Norway

    Oscar A. Lea

  3. Department of Oncology, University of Bergen, Bergen, Norway

    Stener Kvinnsland

Authors
  1. Jon Arne Søreide
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  2. Oscar A. Lea
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  3. Stener Kvinnsland
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Søreide, J.A., Lea, O.A. & Kvinnsland, S. Progesterone binding cyst protein (PBCP) in primary breast cancer: A new prognostic factor?. Breast Cancer Res Tr 9, 123–128 (1987). https://doi.org/10.1007/BF01807364

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  • DOI: https://doi.org/10.1007/BF01807364

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