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Nuclear DNA content and prognosis in human breast cancer: A static cytophotometric study

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Summary

Nuclear DNA content was measured by static cytophotometry in smears from breast carcinomas from 80 women, and the results were correlated with other prognostic variables and survival using multivariate statistical analysis. 49% of patients had diploid tumors and 51% hyperdiploid tumors. There was a strong correlation between DNA ploidy and axillary lymph node status, tumor size, ER status, and short term survival (median follow-up 40 months). Of all parameters measured, ploidy showed the strongest correlation with survival, and was a significant prognostic indicator even when other prognostic factors were taken into account.

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Authors and Affiliations

  1. Hospital and University Departments of Pathology, Queen Elizabeth II Medical Centre, 6009, Nedlands, Western Australia, Australia

    Jennet Harvey, Ian Berryman, Gregory Sterrett & John Papadimitriou

  2. National Health and Medical Research Council Research Unit in Epidemiology and Preventive Medicine, Department of Medicine, University of Western Australia, 6009, Nedlands, Western Australia, Australia

    Nicholas de Klerk

  3. Department of Medical Oncology, Queen Elizabeth II Medical Centre, 6009, Nedlands, Western Australia, Australia

    Michael Byrne

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  1. Jennet Harvey
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  2. Nicholas de Klerk
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  3. Ian Berryman
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  4. Gregory Sterrett
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  5. Michael Byrne
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  6. John Papadimitriou
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Harvey, J., de Klerk, N., Berryman, I. et al. Nuclear DNA content and prognosis in human breast cancer: A static cytophotometric study. Breast Cancer Res Tr 9, 101–109 (1987). https://doi.org/10.1007/BF01807362

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