Breast cancer family history as a risk factor for early onset breast cancer
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Since full breast cancer screening is not generally recommended for young women, it is important to identify individuals who are at higher risk for early onset breast cancer. We investigated the relationship between age of onset of breast cancer in 328 probands (consecutively ascertained patients from our oncology clinic) and breast cancer incidence and age of onset in their female relatives. We found that a family history of early onset breast cancer was associated with higher risk of early onset breast cancer. A family history of early onset breast cancer occurred more frequently among young (<40) breast cancer probands than among older (⩾40) breast cancer probands (p<0.001; OR = 23). This relationship was particularly evident when the analysis was restricted to thehereditary breast cancer probands (p<0.001; OR = 44). We also observed a positive family history of breast cancer (any age) more frequently in young breast cancer probands than in older breast cancer probands (p<0.001; OR = 2.8). These observations have important pragmatic implications for surveillance. We recommend intense surveillance for breast cancer, initiated earlier, for women with close relatives diagnosed with early onset breast cancer.
Key wordsearly onset breast cancer familial breast cancer hereditary breast cancer mammography risk screening
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- 1.Silverberg E: Cancer statistics 1984. Ca 34: 7–23, 1984Google Scholar
- 2.Young JL, Percy CL, Asire AJ: Surveillance, epidemiology, and end results program: incidence and mortality data 1973–1977. NCI Monogr 57: 1–1082, 1981Google Scholar
- 3.Lynch HT: Genetics and Breast Cancer. Van Nostrand Reinhold Co, New York, 1981Google Scholar
- 5.Lynch HT, Lynch JF: Breast cancer genetics in an oncology clinic: 328 consecutive patients. Cancer Genet Cytogenet 23: 369–372, 1986Google Scholar
- 6.Lynch HT, Albano WA, Organ CH, Schmitz GD, Lynch JF: Surveillance and management of hereditary breast cancer. Breast 7: 2–9, 1982Google Scholar
- 8.Lynch HT, Guirgis HA, Brodkey F, Maloney K, Lynch PM, Rankin L, Lynch JF: Early age of onset in familial breast cancer. Arch Surg 111: 125–131, 1976Google Scholar
- 12.Haagensen CD, Haagensen Jr DE, Bodian C: Risk and Detection of Breast Cancer. WB Saunders Co, Philadelphia, 1981, pp 10–13Google Scholar