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Urinary androgen and 17-hydroxylated corticosteroid metabolites and their relation to recurrence rates in early breast cancer

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Summary

The amounts of urinary androsterone and etiocholanolone are highly correlated with recurrence rates in patients with early breast cancer after treatment by mastectomy. A more efficient means of predicting the clinical course of the disease is obtained by using a ratio of these compounds to the amounts of individual 17-hydroxycorticosteroids in the urine. For instance, the ratio of androsterone to a-cortolone is particularly effective in identifying women with a high rate of recurrence, and this is largely independent of pathological stage and tumor grade.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, P.O. Box 123, WC2A 3PX, London, UK

    Brian S. Thomas Ph.D., Richard D. Bulbrook M.Sc., Ph.D & Martin J. Russell B.Sc.

  2. Breast Cancer Unit, Guys Hospital, SE1 9RT, London, UK

    John L. Hayward F.R.C.S. & Rosemary R. Millis M.R.C.Path

Authors
  1. Brian S. Thomas Ph.D.
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  2. Richard D. Bulbrook M.Sc., Ph.D
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  3. Martin J. Russell B.Sc.
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  4. John L. Hayward F.R.C.S.
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  5. Rosemary R. Millis M.R.C.Path
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Thomas, B.S., Bulbrook, R.D., Russell, M.J. et al. Urinary androgen and 17-hydroxylated corticosteroid metabolites and their relation to recurrence rates in early breast cancer. Breast Cancer Res Tr 4, 27–35 (1984). https://doi.org/10.1007/BF01806985

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  • DOI: https://doi.org/10.1007/BF01806985

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