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Corpus luteum dysfunction and the epidemiology of breast cancer: A reconsideration

Breast Cancer Research and Treatment volume 1, pages 287–296 (1981)Cite this article

Summary

Many of the epidemiologic risk factors for the development of breast cancer are related to major events in the female reproductive experience. Several years ago, in an attempt to synthesize these observations, we proposed a theory that focused on abnormal corpus luteum function as a major endocrine determinant of breast cancer risk. This review summarizes the work that has been done attempting to substantiate or refute that hypothesis and reconsiders it in the light of more recent information.

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Authors and Affiliations

  1. Departments of Internal Medicine and Preventive Medicine, University of Iowa College of Medicine, USA

    Barry M. Sherman M.D. & Robert B. Wallace M.D.

  2. Department of Medicine, UCLA-San Fernando Valley Medical Program, USA

    Stanley G. Korenman M.D.

Authors
  1. Barry M. Sherman M.D.
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  2. Robert B. Wallace M.D.
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  3. Stanley G. Korenman M.D.
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Additional information

Address for reprints: Dr. Barry Sherman, Clinical Research Center, University Hospitals, Iowa City, IA 52242, USA.

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Sherman, B.M., Wallace, R.B. & Korenman, S.G. Corpus luteum dysfunction and the epidemiology of breast cancer: A reconsideration. Breast Cancer Res Tr 1, 287–296 (1981). https://doi.org/10.1007/BF01806745

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