Breast Cancer Research and Treatment

, Volume 38, Issue 3, pp 283–288 | Cite as

Impaired hemorheology in patients with postmastectomy lymphedema

  • Manuela P. Djavanmard
  • Ilse Michl
  • M. Korpan
  • Barbara Fazeny
  • Alexandra C. Budinsky
  • Elmar Wiesinger
  • Georg Weinländer
  • Michael Binder
  • Margot Püspök
  • Christoph C. Zielinski
  • Veronika Fialka
  • Renate Koppensteiner
  • Christine Marosi
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Abstract

Lymphedema of the arm is one of the most disabling and serious complications of breast cancer. Apart from tumor infiltration or fibrosis of lymphatic pathways, little is known about factors favoring the development of lymphedema. In the present study, we investigated the impact of rheologic parameters, e.g. red cell aggregation (EA) and plasma viscosity (PV), and of capillary morphology and capillary flow in patients with breast cancer with (n = 18) and without (n = 18) lymphedema. Patients with lymphedema showed a significant increase of red cell aggregation (p < 0.001) that indicates a systemic component of lymphedema and might offer a possibility of prevention and therapy of this condition. A hitherto unclassified protein factor favoring red cell aggregation and lymphedema might be postulated.

Key words

postmastectomy lymphedema rheology volumetry red cell aggregation 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Manuela P. Djavanmard
    • 1
  • Ilse Michl
    • 1
  • M. Korpan
    • 4
  • Barbara Fazeny
    • 1
  • Alexandra C. Budinsky
    • 1
  • Elmar Wiesinger
    • 1
  • Georg Weinländer
    • 1
  • Michael Binder
    • 3
  • Margot Püspök
    • 3
  • Christoph C. Zielinski
    • 1
  • Veronika Fialka
    • 4
  • Renate Koppensteiner
    • 2
  • Christine Marosi
    • 1
  1. 1.Department of Internal Medicine I, Division of clinical oncologyUniversity hospital, ViennaViennaAustria, Europe
  2. 2.Department of Internal Medicine II, Divison of AngiologyUniversity hospital, ViennaViennaAustria, Europe
  3. 3.Department of DermatologyUniversity hospital, ViennaViennaAustria, Europe
  4. 4.Department of Physical Medicine and RehabilitationUniversity hospital, ViennaViennaAustria, Europe

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